Long-term PAS in Rehabilitation After SCI
Long-term Paired Associative Stimulation in Rehabilitation of Spinal Cord Injury Patients
1 other identifier
interventional
5
1 country
1
Brief Summary
The investigators have recently shown in two pilot incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to incomplete SCI patients in a long-term manner, keeping each patient in the study for as long as continuous improvement is observed.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Feb 2017
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 2, 2017
CompletedFirst Posted
Study publicly available on registry
February 7, 2017
CompletedStudy Start
First participant enrolled
February 10, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2023
CompletedMay 13, 2025
May 1, 2025
6.3 years
February 2, 2017
May 12, 2025
Conditions
Outcome Measures
Primary Outcomes (2)
Daniels and Worthingham's Muscle Testing
2 days after the last stimulation session
Daniels and Worthingham's Muscle Testing
1 month after the last stimulation session
Study Arms (1)
incomplete SCI patients
EXPERIMENTALInterventions
Paired associative stimulation (PAS) administered 3 times per week. PAS comprises transcranial magnetic stimulation (eXimia magnetic stimulator, Nexstim Ltd, Helsinki, Finland) and peripheral nerve stimulation (given with Dantec Keypoint® electroneuromyography device (Natus Medical Incorporated, Pleasanton, CA, USA)).
Eligibility Criteria
You may qualify if:
- incomplete SCI
You may not qualify if:
- epilepsy
- pacemaker
- hearing device
- high intracranial pressure
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Helsinki University Central Hospitallead
- Validia Rehabilitationcollaborator
- University of Helsinkicollaborator
Study Sites (1)
BioMag laboratory, Helsinki University Central Hospital
Helsinki, Uusimaa, 00029, Finland
Related Publications (2)
Rodionov A, Savolainen S, Kirveskari E, Makela JP, Shulga A. Restoration of hand function with long-term paired associative stimulation after chronic incomplete tetraplegia: a case study. Spinal Cord Ser Cases. 2019 Oct 1;5:81. doi: 10.1038/s41394-019-0225-5. eCollection 2019.
PMID: 31632739RESULTHolopainen K, Tolmacheva A, Bersch I, Haakana P, Pohjonen M, Kirveskari E, Arokoski J, Shulga A. Stable improvement in hand muscle strength in incomplete spinal cord injury patients by long-term paired associative stimulation-a case series study. Front Neurol. 2025 Feb 4;16:1486591. doi: 10.3389/fneur.2025.1486591. eCollection 2025.
PMID: 39968455RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Anastasia Shulga, MD, PhD
Helsinki University Central Hospital
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principle Investigator
Study Record Dates
First Submitted
February 2, 2017
First Posted
February 7, 2017
Study Start
February 10, 2017
Primary Completion
June 1, 2023
Study Completion
December 1, 2023
Last Updated
May 13, 2025
Record last verified: 2025-05