The Effects of a Train High, Sleep Low Strategy

NCT03045588 | Completed DMC

• 1 other identifier: Sleep low
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

The investigators will examine the long-term effects of a combined training and diet intervention that, acutely, increases fat oxidation during exercise. This is done with a 4 week intervention study with moderately trained cyclists. Performance is tested pre and post intervention and muscle biopsies are obtained.

Conditions

Cycling Performance; Muscular Adaptations; Substrate Utilization

Outcome Measures

Primary Outcomes (1)

• Time trial performance measured in Watts

  30 min time trial after 90 minutes of intensive cycling. The average amount of Watts during the 30 minutes will be measured.

  Change from Baseline and after 4 weeks of training

Secondary Outcomes (2)

• Protein expression in skeletal muscle tissue

  Baseline and after 4 weeks of training

• The absolute amount of carbohydrate and fat which is metabolised during morning exercise, measured in grams/minute

  Baseline and after 4 weeks of training

Study Arms (2)

Low group

EXPERIMENTAL

This subjects in this group conducts all their morning exercise sessions with high fat oxidation (in a fasted condition). Thus, the subjects in this group after high intensity exercise in the evening do not get any carbohydrates to eat after training until the exercise session the following morning has been conducted.

Other: Combined exercise and diet intervention

High group

ACTIVE COMPARATOR

This subjects in this group conducts all their morning exercise sessions with low fat oxidation (in a fed condition). Thus, the subjects in this group after high intensity exercise in the evening do get carbohydrates to eat after training until the exercise session the following morning has been conducted.

Other: Combined exercise and diet intervention

Interventions

Combined exercise and diet intervention OTHER

Both groups exercise 6 times per week in 4 weeks conducted as 3 evening and 3 morning sessions per week. Both groups receive dietary products to be consumed immediately before and after each evening and morning session, respectively. One group conduct morning sessions in a fasted state, the other conduct the morning sessions in a fed state. Performance pre and post is measured, and muscle biopsies are obtained.

High group; Low group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years
• VO2-max\>55 ml/kg/min
• No smokers
• Training 6 hours per week (cycling)
• Training experience for more than 3 years.

You may not qualify if:

• Less than 2 g carbohydrate/kg/day

Sponsors & Collaborators

• University of Aarhus: lead
• Team Denmark: collaborator

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 29, 2017
• First Posted: February 7, 2017
• Study Start: October 1, 2016
• Primary Completion: December 20, 2016
• Study Completion: October 10, 2018
• Last Updated: October 24, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share