Race Adiposity Interactions Regulate Mechanisms Determining Insulin Sensitivity

NCT03043235 | Completed

• 1 other identifier: 2237
• Study Type: observational
• Target: 126
• Locations: 1 country
• Sites: 1

Brief Summary

This research study will examine how ethnic/racial background, body composition (%body fat), and the location of body fat affect the ability of the hormone insulin to promote uptake of blood sugar in persons who are 19 to 45 years of age. When insulin is ineffective in promoting blood sugar uptake, this condition is termed "insulin resistance." Insulin resistance plays a major role in the development of chronic metabolic diseases (such as type 2 diabetes, cardiovascular disease, and cancer), many of which differ with race. Previous studies suggest that insulin resistance is higher in African-Americans (AA) vs. European-Americans (EA). However, results from these studies remain unclear due to different testing measures used for insulin resistance as well as differences in body fat between individuals. Results from this research study may help explain why insulin resistance differs with genetic background and may guide development of personalized treatment strategies with implications for several chronic metabolic diseases (e.g., type 2 diabetes, cardiovascular disease, and cancer).

Conditions

Insulin Sensitivity; Fat; Liver

Outcome Measures

Primary Outcomes (1)

• Hyperinsulinemic isoglycemic glucose clamp

  5 years

Study Arms (4)

African American Females

No intervention

African American Males

No intervention

Caucasian Females

No intervention

Caucasian Males

No intervention

Eligibility Criteria

• Age: 19 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

African American and Caucasian Males and Females between 19-45 years old

You may qualify if:

• African American or Caucasian
• Body Mass Index 19-45
• Do NOT have diabetes
• Exercise less than 2 hours per week
• Are willing to travel to UAB for 2 screens and 4 testing visits

You may not qualify if:

• Diabetes
• Any major medical conditions or medications that interfere with study outcomes

Sponsors & Collaborators

• University of Alabama at Birmingham: lead

Study Sites (1)

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

Location

Related Publications (1)

• Fisher G, Tay J, Warren JL, Garvey WT, Yarar-Fisher C, Gower BA. Sex and race contribute to variation in mitochondrial function and insulin sensitivity. Physiol Rep. 2021 Oct;9(19):e15049. doi: 10.14814/phy2.15049.

  PMID: 34605220 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

DNA will be used to identify ancestry. This information is needed to understand why African Americans and Caucasians have different risks for developing certain diseases.

MeSH Terms

Conditions

Insulin Resistance; Fatty Liver

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Liver Diseases; Digestive System Diseases

Study Officials

• Barbara Gower, PhD

  University of Alabama at Birmingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prinicipal Investigator

Study Record Dates

• First Submitted: February 2, 2017
• First Posted: February 3, 2017
• Study Start: January 8, 2014
• Primary Completion: June 30, 2018
• Study Completion: June 30, 2018
• Last Updated: July 16, 2018

Record last verified: 2018-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)