Serum Lipid Levels and Lp-PLA2 in Chronic Periodontitis

NCT03041480 | Completed DMC

• 1 other identifier: MADC/IRB/2015/91
• Study Type: observational
• Target: 75
• Locations: 0 countries
• Sites: N/A

Brief Summary

To assess the association between periodontal parameters, serum lipid profile and Lp-PLA2 level in systemically healthy Chronic Periodontitis subjects and healthy controls.

Conditions

Chronic Periodontitis (Disorder)

Keywords

chronic periodontitis; lipids; Lp-PLA2

Outcome Measures

Primary Outcomes (1)

• Estimation of serum Lp-PLA2

  Serum Lp-PLA2 was estimated in all the groups using ELISA

  9 months

Secondary Outcomes (1)

• Estimation of serum lipid profile

  9 months

Study Arms (3)

GROUP I

Estimation of serum lipid levels and Lp-PLA2 in generalized severe chronic periodontitis

Diagnostic Test: serum lipid levels and Lp-PLA2

GROUP II

Estimation of serum lipid levels and Lp-PLA2 in generalized moderate chronic periodontitis

Diagnostic Test: serum lipid levels and Lp-PLA2

GROUP III

Estimation of serum lipid levels and Lp-PLA2 in systemically and periodontally healthy controls

Diagnostic Test: serum lipid levels and Lp-PLA2

Interventions

serum lipid levels and Lp-PLA2 DIAGNOSTIC_TEST

Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis

Also known as: Biological marker

GROUP I; GROUP II; GROUP III

Eligibility Criteria

• Age: 35 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population was selected from the Department of Periodontology, Meenakshi Ammal Dental College

You may qualify if:

• Group I:
• Subjects with age ≥ 35 years.
• Presence of at least 24 teeth, with Clinical attachment loss (CAL) ≥ 5mm in more than 30% of sites.
• Group II:
• Subjects with age ≥ 35 years.
• Presence of at least 24 teeth, with Clinical attachment loss (CAL) between 3-4 mm in more than 30% of sites.
• Group III:
• Subjects with age ≥ 35 years.
• Healthy and intact periodontium

You may not qualify if:

• Presence of any systemic disease or conditions that could affect periodontal tissues.
• History of periodontal treatment in past 6 months.
• Smoking and alcoholism
• Anomalies of blood and immune system
• Systemic medication or antibiotic treatment for the previous 6 months.
• Pregnant females.

Sponsors & Collaborators

• Meenakshi Ammal Dental College and Hospital: lead

Related Publications (2)

• Zhou SY, Xiao WM, Ouyang XY. Lipoprotein-associated phospholipase A2 and serum lipid levels in subjects with chronic periodontitis and hyperlipidemia. Chin J Dent Res. 2012;15(1):25-9.

  PMID: 22866279 BACKGROUND

• Fentoglu O, Koroglu BK, Kara Y, Dogan B, Yilmaz G, Sutcu R, Ay ZY, Tonguc MO, Orhan H, Tamer MN, Kirzioglu FY. Serum lipoprotein-associated phospholipase A(2) and C-reactive protein levels in association with periodontal disease and hyperlipidemia. J Periodontol. 2011 Mar;82(3):350-9. doi: 10.1902/jop.2010.100417. Epub 2010 Sep 1.

  PMID: 20809860 BACKGROUND

MeSH Terms

Conditions

Chronic Periodontitis

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Bittu Koshy, BDS

  Meenakshi Ammal Dental College

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 1, 2017
• First Posted: February 2, 2017
• Study Start: February 2, 2015
• Primary Completion: August 23, 2015
• Study Completion: November 26, 2015
• Last Updated: February 2, 2017

Record last verified: 2017-01

Data Sharing

• IPD Sharing: Will not share