Sponsor study identifier
Secondary identifiers
OTHER · Assistance Publique-Hôpitaux de Marseille
interventional
260
1 country
1
Study Start
May 2017
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
February 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
October 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
the investigators hypothesize that hub alteration occurs both in diffuse diseases (MS, AD) as well as in more 'network specific' diseases (Parkinson, ALS, Epilepsy). This could impact on functional dysfunction not directly related to each disease, but that could induce common syndrome such as cognitive impairment observed in Parkinson, partial epilepsy or ALS. The objective here is to test this hypothesis and provides better understandings on pathophysiological processes affecting those highly connected regions in 'diffuse' and 'focal' neurological diseases. The ultimate goal is to identify new clinical targets for trans-nosological approaches (DBS, cognitive rehabilitation ...). Practically, the investigators will explore 200 patients classified in 5 cohorts of 40 patients suffering for MS, AD, Parkinson, ALS, Epilepsy, using the last advanced methods to assess structural and functional brain connectivity implemented on the human 7T MR scanner equipping the CEMEREM (CHU Timone, Marseille, only 50 similar MR scanners worldwide). In addition to high resolution diffusion MRI and rs-fMRI, metabolic and ionic (sodium) mapping will complement the MR protocol to characterize the pathophysiological processes of hub injury. Sixty healthy controls will also be explored wih the same protocol for normal database. The proposal aims at characterizing and comparing from a morphological-functional point of view, the hub regions of patients suffering from these five diseases, to demonstrate the pertinence to preserve hub integrity as a major therapeutic target whatever the disease.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 31, 2017
Actual (reported)February 1, 2017
Actual (reported)May 2017
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
February 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
October 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Index of reorganization of the structural hubs (ks-Degree)
5years
Concentrations of sodium within hubs
5 years
Concentrations of Glutamate/Glutamine within hubs
5 years
cortical Thicknesses within hubs
5 years
Iron accumulation within hubs
5 years
Assiatnce Publique Hopitaux de Marseille
Marseille, 13354, France
Catherine GEINDRE
Assistance Publique Hopitaux De Marseille
First Submitted
January 31, 2017
First Posted
February 1, 2017
Study Start
May 2017
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
February 2022
Estimated (date passed)Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
October 2022
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
April 14, 2017
Record last verified: 2017-04
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Source: ClinicalTrials.gov.
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