Cognitive Intervention to Improve Memory in Heart Failure Patients
Memoir-HF
1 other identifier
interventional
276
1 country
2
Brief Summary
Cognitive Intervention to Improve Memory in Heart Failure patients
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Feb 2017
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 12, 2017
CompletedFirst Posted
Study publicly available on registry
January 30, 2017
CompletedStudy Start
First participant enrolled
February 22, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 6, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2021
CompletedFebruary 17, 2023
February 1, 2023
3.7 years
January 12, 2017
February 15, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change in delayed recall memory as measured by Hopkins Verbal Learning Test
Change in delayed recall memory as measured by Hopkins Verbal Learning Test
At 8 months
Change in serum brain derived neurotrophic factor ( BDNF) Level
Co-Primary Outcome
At 8 months
Secondary Outcomes (4)
Change in working memory as measured by CogState One Back Accuracy Task
At 8 months
Change in instrumental activities of daily living as measured by Everyday Problems Test
At 8 months
Change in health-related quality of life as measured by Minnesota Living with Heart Failure Questionnaire
At 8 months
Cost-effectiveness of the Brain HQ training intervention as measured by calculating the Incremental cost effectiveness ratios (ICERs) using medical services costs
At 8 months
Other Outcomes (1)
Cognitive Intervention to Improve Memory in Heart Failure Patients - Supplement
Across 36 months
Study Arms (3)
Computerized Cognitive Training Brain HQ
EXPERIMENTALComputerized cognitive training intervention using Brain HQ initiated and continued 1 hour/day, 5 days/week for 8 weeks
Computerized Crossword Puzzles
ACTIVE COMPARATORGeneral cognitive stimulation puzzles intervention initiated and continued 1 hour/day, 5 days/week for 8 weeks
Usual Care
NO INTERVENTIONNo computerized cognitive intervention
Interventions
Computerized Cognitive Training Brain HQ activities initiated and continued 1 hour/day, 5 days/week for 8 weeks
Computerized Crossword Puzzles activities initiated and continued 1 hour/day, 5 days/week for 8 weeks
Eligibility Criteria
You may qualify if:
- At least 21 years of age
- Understands English
- Has access to a telephone
- Hears normal conversation
- For patients with hearing aids, able to wear and hear through headsets
- Diagnosis of chronic heart failure, stage C, NYHA I, II or III
- Receiving guideline derived medical therapy
- Heart failure validated by echocardiography or other method in past 2 years
- Able to read a computer screen with or without glasses or lenses
You may not qualify if:
- History of drug or alcohol abuse or major psychiatric diagnosis present before the heart failure diagnosis
- Alzheimer or other dementia diagnosis or central nervous system degenerative disorder
- Terminal cancer
- Patients with baseline Montreal Cognitive Assessment (MoCA) score of less than 19
- Supplement Eligibility: First 144 patients randomized in the parent trial.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Indiana University Health
Indianapolis, Indiana, 46202, United States
Methodist Hospital-Krannert Institute of Cardiology
Indianapolis, Indiana, 46202, United States
Related Publications (5)
Pressler SJ, Giordani B, Titler M, Gradus-Pizlo I, Smith D, Dorsey SG, Gao S, Jung M. Design and Rationale of the Cognitive Intervention to Improve Memory in Heart Failure Patients Study. J Cardiovasc Nurs. 2018 Jul/Aug;33(4):344-355. doi: 10.1097/JCN.0000000000000463.
PMID: 29601367BACKGROUNDAlgashgari EY, Jung M, Von Ah D, Stewart JC, Pressler SJ. Perceived Facilitators and Barriers to Treatment Fidelity in Computerized Cognitive Training Interventions. J Cardiovasc Nurs. 2022 Apr 20. doi: 10.1097/JCN.0000000000000916. Online ahead of print.
PMID: 35467571BACKGROUNDHalloway S, Jung M, Yeh AY, Liu J, McAdams E, Barley M, Dorsey SG, Pressler SJ. An Integrative Review of Brain-Derived Neurotrophic Factor and Serious Cardiovascular Conditions. Nurs Res. 2020 Sep/Oct;69(5):376-390. doi: 10.1097/NNR.0000000000000454.
PMID: 32555009BACKGROUNDPressler SJ, Jung M, Gradus-Pizlo I, Titler MG, Smith DG, Gao S, Lake KR, Burney H, Clark DG, Wierenga KL, Dorsey SG, Giordani B. Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure. J Card Fail. 2022 Apr;28(4):519-530. doi: 10.1016/j.cardfail.2021.10.008. Epub 2021 Nov 8.
PMID: 34763080RESULTSmith AB, Jung M, Pressler SJ, Mocci E, Dorsey SG. Differential Gene Expression Among Patients With Heart Failure Experiencing Pain. Nurs Res. 2023 May-Jun 01;72(3):175-184. doi: 10.1097/NNR.0000000000000648. Epub 2023 Feb 26.
PMID: 36920122DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Susan J Pressler, PhD, RN
Indiana University School of Medicine
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- FACTORIAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
January 12, 2017
First Posted
January 30, 2017
Study Start
February 22, 2017
Primary Completion
November 6, 2020
Study Completion
September 30, 2021
Last Updated
February 17, 2023
Record last verified: 2023-02
Data Sharing
- IPD Sharing
- Will share