NCT03022669

Brief Summary

The purpose of this study is to determine whether text messages/messaging (TM) or a mobile application (app), compared with an educational website-control provided to all Veterans, can improve adherence to antiplatelet therapy among patients following acute coronary syndrome or percutaneous coronary intervention (ACS/PCI).

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
225

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Dec 2016

Longer than P75 for not_applicable

Geographic Reach
1 country

5 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2016

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

January 12, 2017

Completed
4 days until next milestone

First Posted

Study publicly available on registry

January 16, 2017

Completed
5.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2022

Completed
Last Updated

September 29, 2021

Status Verified

September 1, 2021

Enrollment Period

5.8 years

First QC Date

January 12, 2017

Last Update Submit

September 27, 2021

Conditions

Keywords

mobile healthveteranscardiovascular diseasemedication adherence

Outcome Measures

Primary Outcomes (5)

  • Change in medication adherence over 12 months

    Medication Event Monitoring System (MEMS) which is an electronic pill bottle cap that captures medication taking patterns

    12 months

  • Change in medication adherence over 12 months

    Adherence to Refills and Medications Scale (ARMS)- There are two subscale scores for medication taking and medication refills. The total score is found by adding both subscales. Scores can range from 12 to 48 with 12 being completely medication adherent and 48 being completely non-adherent.

    12 months

  • Change in medication adherence at 12 months

    Medication recall questionnaire that will assess how many missed doses there were.

    12 months

  • Change in medication adherence at 12 months

    VA Corporate Data Warehouse refill data (Veteran participants)

    12 months

  • Change in medication adherence at 12 months

    Peoplechart Meds Incontext refill data (non-Veteran participants)

    12 months

Study Arms (3)

Text Message Group

EXPERIMENTAL

The "TM group" will use the VA "Annie" text messaging program to remind patients to take antiplatelet medications. The content for the text messages will be determined through preliminary focus groups that will be conducted prior to the RCT.

Behavioral: Text MessageOther: Website

Application Group

EXPERIMENTAL

The "App group" will use a mobile application to remind patients to take antiplatelet medications. The commercially available mobile app will be selected by participants through preliminary focus groups that will be conducted prior to the RCT.

Behavioral: Mobile ApplicationOther: Website

Website-Control

EXPERIMENTAL

The "Website-Control group" will will be offered the American Heart Association patient education website (My Life Check - 7 Steps To Healthy Living) and will serve as an "attention-control." The website will be offered to participants in all three groups. The "7 small steps to big changes" are to manage blood pressure, control cholesterol, reduce blood sugar, get active, eat better, lose weight, and stop smoking.

Other: Website

Interventions

Text MessageBEHAVIORAL

Annie (VA text messaging program) or mobile Health manager (private text messaging program for non-VA female participants recruited at non-VA facility)

Text Message Group
Application Group
WebsiteOTHER

American Heart Association patient education website

Application GroupText Message GroupWebsite-Control

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • ≥ 21 years of age,
  • recent ACS or PCI within 1 week
  • new antiplatelet (thienopyridine) prescription
  • owns a smartphone

You may not qualify if:

  • cognitive impairment
  • lack of English proficiency/literacy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (5)

John Muir Medical Center

Concord, California, 94520, United States

RECRUITING

VA Palo Alto Health Care System

Palo Alto, California, 94304, United States

RECRUITING

San Francisco Veterans Affairs Medical Center

San Francisco, California, 94121, United States

RECRUITING

North Florida/South Georgia Veterans Health System

Gainesville, Florida, 32608, United States

RECRUITING

VA North Texas Health Care System

Dallas, Texas, 75216, United States

RECRUITING

Related Publications (1)

  • Park LG, Collins EG, Shim JK, Whooley MA. Comparing Mobile Health Strategies to Improve Medication Adherence for Veterans With Coronary Heart Disease (Mobile4Meds): Protocol for a Mixed-Methods Study. JMIR Res Protoc. 2017 Jul 18;6(7):e134. doi: 10.2196/resprot.7327.

MeSH Terms

Conditions

Coronary DiseaseCardiovascular DiseasesMedication Adherence

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesVascular DiseasesPatient CompliancePatient Acceptance of Health CareTreatment Adherence and ComplianceHealth BehaviorBehavior

Study Officials

  • Linda Park, PhD

    San Francisco Veterans Medical Center; University of California, San Francisco

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Linda Park, PhD, MS, FNP

CONTACT

Julia von Oppenfeld

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
FED
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

January 12, 2017

First Posted

January 16, 2017

Study Start

December 1, 2016

Primary Completion

September 30, 2022

Study Completion

September 30, 2022

Last Updated

September 29, 2021

Record last verified: 2021-09

Locations