The Effect of a Caffeine Blend on Reaction Time, Mental Performance and Focus in Athletic Males

NCT03019523 | Completed

• 1 other identifier: NBTY-1
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

This is a cross-over design study in which subjects arrived to the lab and were assigned a supplement to ingest. Prior to ingestion subjects completed baseline reaction time testing along with a questionnaire. Thirty minutes after ingestion subjects filled out the same questionnaire, completed a reaction time test, followed by a series of dynamic exercises. After the last exercise was finished subjects filled out the questionnaire, completed another reaction time test and repeated the series of dynamic exercises. Following the exercises, subjects filled out the questionnaire and completed a fourth round of reaction time testing. In total subjects would complete 2 rounds of dynamic exercises and 4 rounds of reaction time testing with heart rate being recorded before and after the dynamic exercise rounds. Subjects were told to wash-out for 7 days and return to the lab to complete the same testing but on the alternative supplement.

Conditions

Mental Fatigue

Keywords

caffeine; mental performance; reaction time; focus

Outcome Measures

Primary Outcomes (3)

• Response to Caffeine on Measures of Reaction Time by Makoto

  The primary purpose of this investigation is to determine if acute ingestion of a proprietary supplement containing caffeine, theanine, and tyrosine has any positive effects on markers of reaction time in athletic populations.

  up to 4 hours

• Response to Caffeine on Measures of Mental Performance by Survey in Athletic Populatons

  The primary purpose of this investigation is to determine if acute ingestion of a proprietary supplement containing caffeine, theanine, and tyrosine has any positive effects on markers of mental performance in athletic populations.

  up to 4 hours

• Response to Caffeine on Measures of Cognitive Fatigue by Survey in Athletic Populatons

  The primary purpose of this investigation is to determine if acute ingestion of a proprietary supplement containing caffeine, theanine, and tyrosine has any positive effects on markers of cognitive fatigue in athletic populations.

  up to 4 hours

Secondary Outcomes (1)

• Response to Caffeine on Measures of Physical Performance by Comparing the Total Amount of Work Completed

  up to 4 hours

Study Arms (2)

Sugar Pill

PLACEBO COMPARATOR

Maltodextrin (\~2 grams to match weight of active treatment) placebo pre-testing (1 dose w/3 oz of water) 30 minutes following ingestion exercise and Makoto testing were completed.

Other: Sugar Pill

Caffeine Blend

ACTIVE COMPARATOR

75 mg caffeine, 75 mg theanine, and 2g tyrosine pre-testing (1 dose w/3 oz of water) 30 minutes following ingestion exercise and Makoto testing were completed.

Dietary Supplement: Caffeine Blend

Interventions

Caffeine Blend DIETARY_SUPPLEMENT

Taken orally in capsule form

Caffeine Blend

Sugar Pill OTHER

Taken orally in capsule form

Sugar Pill

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Subjects will be males between the ages of 18-25 years
• Subjects will be team sport athletes or highly trained
• Subjects will not be able to smoke or use tobacco
• Subjects has provided written and dated informed consent to participate in the study
• Subjects is willing and able to comply with the protocol
• Subjects is apparently healthy and free from disease, as determined by a health history questionnaire
• Subjects is a regular caffeine consumer (up to 2 cups of coffee a day)
• Subjects agrees to abstain from caffeine the day of each testing session
• Subjects agrees to abstain from exercise 24 hours prior to each testing visit. 48 hours prior to the testing session, the subject should not do anything new or unaccustomed in the form of exercise and should not increase the intensity of their workouts.

You may not qualify if:

• Subject has not been participating in regular physical activity and exercise trained for at least 12 months prior to enrollment
• Subject is diagnosed with any metabolic or chronic disease, or is on prescription medication for the diagnosed metabolic or chronic disease
• Subject is using, or has used a dietary supplement (other than a multi-vitamin/-mineral, protein powder, or meal replacements) within 6 weeks prior to enrollment. Protein/Meal Replacement Products (MRPs) must not contain any supplements such as creatine, beta-alanine, hydroxyl methlybutyrate (HMB), etc.
• Subject is in, or has participated in another clinical trial within 8 weeks prior to enrollment
• Subject has a known allergy or sensitivity to caffeine or other stimulants (determined from health history questionnaire.

Sponsors & Collaborators

• University of Mary Hardin-Baylor: lead
• NBTY, Inc.: collaborator

Study Sites (1)

UMHB Human Performance Lab

Belton, Texas, 76513, United States

Location

Related Publications (1)

• Zaragoza J, Tinsley G, Urbina S, Villa K, Santos E, Juaneza A, Tinnin M, Davidson C, Mitmesser S, Zhang Z, Taylor L. Effects of acute caffeine, theanine and tyrosine supplementation on mental and physical performance in athletes. J Int Soc Sports Nutr. 2019 Nov 26;16(1):56. doi: 10.1186/s12970-019-0326-3.

  PMID: 31771598 DERIVED

MeSH Terms

Conditions

Mental Fatigue

Interventions

Sugars

Condition Hierarchy (Ancestors)

Fatigue; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Carbohydrates

Study Officials

• Lemuel W Taylor, PhD

  UMHB Human Performance Lab

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director, Exercise Biochemistry Laboratory

Study Record Dates

• First Submitted: December 15, 2016
• First Posted: January 12, 2017
• Study Start: August 1, 2016
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: January 25, 2017

Record last verified: 2017-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)