Neurophysiology of Surround Inhibition in the Human Motor Cortex

NCT03018262 | Completed FDA Device

• 2 other identifiers: 17003117-N-0031
• Study Type: observational
• Target: 53
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Movement disorders have many different causes and symptoms. Researchers still do not fully understand which parts of the brain are involved in fine movement. They want to learn about which brain regions could be abnormal in people with movement disorders. Objective: To better understand how the brain controls movement. Eligibility: Healthy, right-handed adults age 18-70 years old. Design: Participants will be screened with a physical exam and questions about their handedness. They may have a urine test. Participants will have 1 or 2 clinic visits. The first visit will last about 1.5 hours. The second will last about 3 hours. Participants will have structural magnetic resonance imaging (MRI). A strong magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal cylinder. Participants may have transcranial magnetic stimulation. A wire coil is held on the scalp. A brief electrical current is passed through the coil and creates a magnetic pulse that stimulates the brain. Participants will wear a pair of glasses or a headband with small sensors so researchers can track head position. Participants will perform a simple index finger movement task. Participants may have surface electromyography from at least two hand muscles. Small metal disk or adhesive pad electrodes will be taped to the skin. Participants will be seated in a comfortable chair with their hands placed on a pillow. Participants may have an electroencephalography. A cap with small disc electrodes will be placed on the scalp.

Conditions

Normal Physiology

Keywords

Surround Inhibition; Motor Control; Transcranial Magnetic Stimulation (TMS); TMS-Evoked Potential

Outcome Measures

Primary Outcomes (5)

• Substudy 2 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single /paired pulse TMS at rest or movement onset will give information about the corticospinal excitability.

  TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single/paired pulse TMS at rest or movement onset will give information about the corticospinal excitability.

  throughout

• Substudy 1 EEG analysis: we will measure the latency and amplitude of the different components of the TMS-evoked potentials

  EEG: For the EEG analysis, we will measure the latency and amplitude of the different components of the TMS-evoked potentials. Time-frequency analysis on the collected EEG data will provide valuable information on which frequency bands are involved in the phenomenon of motor SI. The coherence calculated between relevant brain regions will also reveal information on the changes in cortical connectivity during the phenomenon of SI.

  throughout

• Substudy 1 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal

  TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single/paired pulse TMS will give information about the corticospinal excitability. The latency of the MEP will revealmore information on which neuronal networks were activated.

  throughout

• Substudy 3 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single pulse TMS at rest or during a motor task will give information about the corticospinal excitability.

  TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single pulse TMS at rest or during a motor task will give information about the corticospinal excitability.

  throughout

• Substudy 3 EMG: The EMG amplitude during certain tasks will reveal information about the level of muscle activation.

  EMG: The EMG amplitude during certain tasks will reveal information about the level of muscle activation.

  throughout

Study Arms (3)

Healthy Volunteers - Sub-study 1

Healthy Volunteers

Device: TMS - sub-study 1

Healthy Volunteers - Sub-study 2

Healthy Volunteers

Device: TMS - sub-study 2

Healthy Volunteers - Sub-study 3

Healthy Volunteers

Device: TMS - sub-study 3

Interventions

TMS - sub-study 1 DEVICE

TMS pulses will be applied to the motor hotspot of the surround muscle to identify the TMS-evoked potentials corresponding to motor surround inhibition (SI)

Healthy Volunteers - Sub-study 1

TMS - sub-study 2 DEVICE

TMS will be used to stimulate the motor cortex and an inhibitory region of the inferior parietal lobe

Healthy Volunteers - Sub-study 2

TMS - sub-study 3 DEVICE

TMS pulses will be delivered to the primary motor cortex at rest, at the onset of the motor task, or during the motor task

Healthy Volunteers - Sub-study 3

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy Volunteers

You may qualify if:

• Age between 18 - 70 years.
• Right-handed (tested by the Edinburg handedness inventory).
• Able to give informed consent.
• Able to comply with all study procedures.
• Abstain from alcohol for at least 48 hrs prior to the study and caffeine on the day of the study (based on oral interview).

You may not qualify if:

• Illegal drug use within the past 6 months based on history alone. The intent is to exclude those with drug use that may affect study results.
• Self-reported consumption of \>14 alcoholic drinks/week for a man and \>7 alcoholic drinks/week for a woman.
• Abnormal findings on neurological examination.
• History of or current brain tumor, stroke, head trauma with loss of consciousness, epilepsy or seizures.
• Current episode of major depression or any major psychiatric illness.
• Taking medications that act directly on the central nervous system such as anti-epileptics, anti-histamines, anti-parkinsonian medication, muscle relaxants, medication for insomnia, anti-depressants, anti-anxiety medication.
• Presence of any metal in the eye or skull area such as a brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, metal fragments in the eye.
• Presence of pacemaker, intracardiac lines, implanted pumps or stimulators or metal objects inside the eye or skull.
• Known hearing loss.
• NIH employees and/or staff.
• Pregnancy
• We will follow the Clinical Radiology/NMR Center guidelines for MR safety.
• Have non-MRI compatible metal in the body, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain or on blood vessels, cochlear implants, artificial heart valves or metal fragments in the eye as these make having an MRI unsafe.
• Have metallic dental fillings which are likely to cause MRI artifacts
• Unable to lie flat on the back for the expected length of the experiment,

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

Location

Related Links

• NIH Clinical Center Detailed Web Page

Study Officials

• Mark Hallett, M.D.

  National Institute of Neurological Disorders and Stroke (NINDS)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 11, 2017
• First Posted: January 12, 2017
• Study Start: February 7, 2017
• Primary Completion: March 24, 2021
• Study Completion: March 24, 2021
• Last Updated: November 24, 2023

Record last verified: 2023-11

Locations

US (1)