Swimming Pool Environment Impact on the Human Respiratory Health

NCT03017976 | Unknown

• 1 other identifier: NORTE-01-0145-FEDER-000010
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to assess the influence of exposure to swimming pool environment on respiratory symptoms and diseases, and on cancer outcomes among swimmers and swimming pool attendants.

Conditions

Asthma; Lung Disease; Genotoxicity

Outcome Measures

Primary Outcomes (5)

• Spirometry with bronchodilation

  First week after recruitment

• Airway resistance measurement

  First week after recruitment

• Airway reactance measurement

  First week after recruitment

• Fractional concentration of orally exhaled nitric oxide

  First week after recruitment

• Volatile organic compounds in the exhaled breath condensate

  First week after recruitment

Secondary Outcomes (3)

• Diagnosis of immunoglobulin E (IgE) mediated allergies by skin prick testing

  First week after recruitment

• Autonomic nervous system function assessment by pupillometry

  First week after recruitment

• Transepidermal water loss

  First week after recruitment

Study Arms (2)

Competitive swimmers

Regular and naïf competitive swimmers will be followed for a mean period of 90 days. A battery of measurements and biological samples will be collected at the baseline evaluation and 90 days after, in order to evaluate long-term changes in respiratory health biomarkers. Measurements will also be performed before and after a single regular training session in order to assess acute effects in respiratory health biomarkers.

Recreational swimmers and swimming pool staff

Swimming pool physicochemical and microbiological characteristics and the association between each parameter measured as an indicator of water and air quality, contamination of surfaces will be evaluated and the association with recreational users, swimming teachers and pool attendants health parameters will be studied.

Eligibility Criteria

• Age: 12 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Competitive swimmers, recreational users and swimming pool workers attending chlorinated and brominated public indoor municipal swimming pools in the North of Portugal.

Competitive swimmers, recreational swimmers or pool workers of a participating indoor swimming pool; Individuals with 12 years of age or older; Individuals who provide (or their caregivers) a signed informed consent.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Universidade do Porto: lead

Study Sites (1)

Faculty of Medicine of Porto University

Porto, Porto District, 4200-319, Portugal

Location

Biospecimen

Retention: SAMPLES WITH DNA

Exhaled breath condensate (no DNA) Blood (DNA) Urine (DNA)

MeSH Terms

Conditions

Asthma; Lung Diseases

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 22, 2016
• First Posted: January 11, 2017
• Study Start: January 1, 2017
• Primary Completion: March 1, 2017
• Study Completion: July 1, 2018
• Last Updated: January 11, 2017

Record last verified: 2016-10

Data Sharing

• IPD Sharing: Will not share

Locations

PT (1)