Metabolic Phenotypes in Childhood Obesity

NCT03014856 | Completed

• 1 other identifier: LCRP-OBNMR
• Study Type: observational
• Target: 102
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study provides a sound basis towards a better understanding of the biochemical mechanisms behind childhood obesity and its metabolic phenotypes, which will be of great importance towards the development of more personalized prevention and treatment in future.

Conditions

Obesity, Pediatric

Keywords

Metabolic syndrome; Metabolomics; NMR spectroscopy

Outcome Measures

Primary Outcomes (1)

• metabolic phenotype of childhood obesity

  Significant metabolic changes in blood plasma of obese children and adolescents and normal-weight control subjects

  day 1

Secondary Outcomes (1)

• metabolic phenotype of metabolically healthy and unhealthy obese children and adolescents

  day 1

Study Arms (2)

OB-NMR

overweight and obese children and adolescents

Other: Blood sampling

NMR-C

normal-weight children and adolescents

Other: Blood sampling

Interventions

Blood sampling OTHER

Determine the metabolic phenotype of blood plasma by proton-NMR spectroscopy

NMR-C; OB-NMR

Eligibility Criteria

• Age: 8 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

65 overweight and obese (OB) children and 37 normal-weight (NW) controls aged 8 to 18 years

You may qualify if:

• aged 8 to 18
• normal-weight, overweight or obese according to the International Obesity Task Force (IOTF) Body Mass Index (BMI) criteria
• fasted for at least 8 hours

You may not qualify if:

• Subjects taking any medication or having serious chronic or acute illness within two weeks preceding the clinical examination,

Sponsors & Collaborators

• Hasselt University: lead
• Jessa Hospital: collaborator

Related Publications (7)

• Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, Nicholson JK. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc. 2007;2(11):2692-703. doi: 10.1038/nprot.2007.376.

  PMID: 18007604 BACKGROUND

• Prince RL, Kuk JL, Ambler KA, Dhaliwal J, Ball GD. Predictors of metabolically healthy obesity in children. Diabetes Care. 2014 May;37(5):1462-8. doi: 10.2337/dc13-1697. Epub 2014 Feb 26.

  PMID: 24574347 BACKGROUND

• Butte NF, Liu Y, Zakeri IF, Mohney RP, Mehta N, Voruganti VS, Goring H, Cole SA, Comuzzie AG. Global metabolomic profiling targeting childhood obesity in the Hispanic population. Am J Clin Nutr. 2015 Aug;102(2):256-67. doi: 10.3945/ajcn.115.111872. Epub 2015 Jun 17.

  PMID: 26085512 BACKGROUND

• Perng W, Gillman MW, Fleisch AF, Michalek RD, Watkins SM, Isganaitis E, Patti ME, Oken E. Metabolomic profiles and childhood obesity. Obesity (Silver Spring). 2014 Dec;22(12):2570-8. doi: 10.1002/oby.20901. Epub 2014 Sep 24.

  PMID: 25251340 BACKGROUND

• Mihalik SJ, Michaliszyn SF, de las Heras J, Bacha F, Lee S, Chace DH, DeJesus VR, Vockley J, Arslanian SA. Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation. Diabetes Care. 2012 Mar;35(3):605-11. doi: 10.2337/DC11-1577. Epub 2012 Jan 20.

  PMID: 22266733 BACKGROUND

• Wahl S, Yu Z, Kleber M, Singmann P, Holzapfel C, He Y, Mittelstrass K, Polonikov A, Prehn C, Romisch-Margl W, Adamski J, Suhre K, Grallert H, Illig T, Wang-Sattler R, Reinehr T. Childhood obesity is associated with changes in the serum metabolite profile. Obes Facts. 2012;5(5):660-70. doi: 10.1159/000343204. Epub 2012 Oct 4.

  PMID: 23108202 BACKGROUND

• Bervoets L, Massa G, Guedens W, Reekmans G, Noben JP, Adriaensens P. Identification of metabolic phenotypes in childhood obesity by 1H NMR metabolomics of blood plasma. Future Sci OA. 2018 May 23;4(6):FSO310. doi: 10.4155/fsoa-2017-0146. eCollection 2018 Jul.

  PMID: 30057787 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood plasma for proton-NMR spectroscopy

MeSH Terms

Conditions

Pediatric Obesity; Metabolic Syndrome

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Peter Adriaensens, PhD

  Institute of Material Research, Hasselt University

  PRINCIPAL INVESTIGATOR

• Liene Bervoets, PhD

  Hasselt University

  STUDY CHAIR

• Guy Massa, PhD, MD

  Jessa Ziekenhuis Hasselt

  STUDY CHAIR

• Wanda Guedens, PhD

  Institute of Material Research, Hasselt University

  STUDY CHAIR

• Gunter Reekmans, Ing

  Institute of Material Research, Hasselt University

  STUDY CHAIR

• Jean-Paul Noben, PhD

  BIOMED, Hasselt University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor (hoogleraar)

Study Record Dates

• First Submitted: December 13, 2016
• First Posted: January 9, 2017
• Study Start: May 1, 2012
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2014
• Last Updated: January 9, 2017

Record last verified: 2017-01