CTCs and Novel Target Bio-marker Analysis for Prediction and Monitoring of Metastasis/Recurrence in Post-surgery Colorectal Cancer Patients Using MiSelect R Rare Cell System

NCT03013868 | Unknown

• 1 other identifier: MiC-SRS-CRC-001
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Despite the growing public awareness and recent progress in multimodality therapy to the colorectal cancer (CRC), CRC still ranks high on the list of the most common and deadly cancers in Taiwan. The cause of CRC mortality is due mainly to the occurrence of distant metastasis. Several reports suggested that circulating tumor cells (CTCs) highly associated with metastasis suggesting that targeting CTCs may offer an unprecedented opportunity to prevent the development of metastasis. Early detection and characterization of CTCs is therefore important as a potential strategy to monitor the progression of CRC. The current proposal is focused on detecting CTCs from peripheral blood of CRC patients using Miselect R system. We will monitor the amount of CTCs and correlate with CRC progression and prognosis.

Conditions

Circulating Tumor Cells, CTC

Outcome Measures

Primary Outcomes (1)

• Disease Free Survival

  5 years

Eligibility Criteria

• Age: 20 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

200 Colorectal cancer stage II/III patients who will undergo surgical resection

You may qualify if:

• Over 20 and less than 90 years of age.
• Colorectal cancer stage II/III patients who will undergo surgical resection.
• Subject having agreed to participate in the study and follow the study procedures by providing written informed consent prior entering the study.

You may not qualify if:

• Have other cancer history.
• Subject being identified with any blood borne infectious disease

Sponsors & Collaborators

• MiCareo Taiwan Co., Ltd.: lead

Study Sites (1)

Taipei Veterans General Hospital

Taipei, 11217, Taiwan

RECRUITING

MeSH Terms

Conditions

Neoplastic Cells, Circulating

Condition Hierarchy (Ancestors)

Neoplasm Metastasis; Neoplastic Processes; Neoplasms; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Wang Henry, Master

CONTACT

886-2-2796-5096; henrywang@micareo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2017
• First Posted: January 9, 2017
• Study Start: October 1, 2016
• Primary Completion: December 1, 2020
• Study Completion: February 1, 2021
• Last Updated: August 16, 2018

Record last verified: 2018-05

Locations

TW (1)