Intergenerational Blood Pressure Study

NCT03013179 | Completed

• 2 other identifiers: 13110129865R01NR013520
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This project, the Intergenerational Blood Pressure Study, is a 5 year research study funded by the National Institutes of Health/National Institute of Nursing Research and led by the Yale University School of Nursing and The Consultation Center at the Yale University School of Medicine, Department of Psychiatry in partnership with Head Start programs across CT. The investigators seek to reduce hypertension health disparities among underserved Black/African American children and their mothers by conducting community-based research to better understand the genetic, psychological, and environmental factors that may contribute to high blood pressure.

Conditions

Hypertension

Outcome Measures

Primary Outcomes (1)

• Blood Pressure

  Manual blood pressure taken according to JNC-7 guidelines, average of 3 resting blood pressure measurements

  18 months

Study Arms (1)

Black/African American Women and their 3-5 year old children

Eligibility Criteria

• Age: 3 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Black/African American women and their 3-5 year old children in CT

You may qualify if:

• Mothers must:
• Self-identify as Black/African American
• Be 21 years or older
• Have a 3-5 year old biological child
• Not be impaired by a though disorder, psychosis, or mania
• Confirm that their child will be able to provide saliva sample for DNA
• Be English-speaking

You may not qualify if:

• None

Sponsors & Collaborators

• Yale University: lead
• National Institute of Nursing Research (NINR): collaborator
• Emory University: collaborator

Study Sites (1)

Yale University School of Nursing

Orange, Connecticut, 06477, United States

Location

Related Publications (3)

• Taylor JY, Wright ML, Crusto CA, Sun YV. The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) Study: Design and Methods for Complex DNA Analysis. Biol Res Nurs. 2016 Oct;18(5):521-30. doi: 10.1177/1099800416645399. Epub 2016 Apr 26.

  PMID: 27118148 BACKGROUND

• Crusto CA, Barcelona de Mendoza V, Connell CM, Sun YV, Taylor JY. The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study (InterGEN): Design and Methods for Recruitment and Psychological Measures. Nurs Res. 2016 Jul-Aug;65(4):331-8. doi: 10.1097/NNR.0000000000000163.

  PMID: 27362519 BACKGROUND

• Barcelona de Mendoza V, Wright ML, Agaba C, Prescott L, Desir A, Crusto CA, Sun YV, Taylor JY. A Systematic Review of DNA Methylation and Preterm Birth in African American Women. Biol Res Nurs. 2017 May;19(3):308-317. doi: 10.1177/1099800416669049. Epub 2016 Sep 19.

  PMID: 27646016 BACKGROUND

Related Links

• Click here for more information about this study: Intergenerational Blood Pressure Study

Biospecimen

Retention: SAMPLES WITH DNA

Saliva sample for DNA

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Jacquelyn Y Taylor, PhD

  Yale University

  PRINCIPAL INVESTIGATOR

• Cindy A Crusto, PhD

  Yale University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2017
• First Posted: January 6, 2017
• Study Start: April 1, 2015
• Primary Completion: June 1, 2019
• Study Completion: March 1, 2020
• Last Updated: March 20, 2020

Record last verified: 2020-03

Data Sharing

• IPD Sharing: Will share

Locations

US (1)