NCT02999594

Brief Summary

Tramadol for labor analgesia: a low risk placebo controlled randomised control trial

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
86

participants targeted

Target at P50-P75 for phase_2

Timeline
Completed

Started Dec 2016

Shorter than P25 for phase_2

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2016

Completed
1 day until next milestone

First Submitted

Initial submission to the registry

December 2, 2016

Completed
19 days until next milestone

First Posted

Study publicly available on registry

December 21, 2016

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2018

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2018

Completed
Last Updated

December 23, 2016

Status Verified

December 1, 2016

Enrollment Period

1.3 years

First QC Date

December 2, 2016

Last Update Submit

December 22, 2016

Conditions

Outcome Measures

Primary Outcomes (1)

  • visual analogue scale

    visual analogue scale i.e scaling of severity of pain from 1 being mildest and 10 being most severe will be assessed at 2nd hour of administration

    at 2nd hour of administration

Secondary Outcomes (6)

  • patient satisfaction

    at the end of labor( within 12 hours)

  • fetal distress

    during labor

  • duration of 1st and 2nd stage of labor

    1st and 2nd stage

  • women with side effects like postpartum haemorrhage, nausea, vomiting and increased sleepiness

    till the end of labor

  • neonatal safety in terms of apgar score and nicu admission

    apgar score at 0 and 5 min

  • +1 more secondary outcomes

Study Arms (2)

tramadol

EXPERIMENTAL

50mg tramadol hydrochloride will be used intramuscularly as an experimental drug for evaluating its safety and efficacy as labor analgesic

Drug: Tramadol Hydrochloride

distilled water

PLACEBO COMPARATOR

2ml distilled water intramuscularly will be used as a placebo.

Drug: Distilled Water

Interventions

50mg intramuscularly

tramadol

2ml intramuscularly

distilled water

Eligibility Criteria

Sexfemale
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • delivering for first time(nulliparous)
  • well established labor ( 3 or more contractions in a span of ten minutes
  • cervical dilation of 4 cm or more
  • \>= 80% effacement of cervix

You may not qualify if:

  • any medical disorder- diabetes,hypertension
  • obstetric high risk factors

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Interventions

Tramadol

Intervention Hierarchy (Ancestors)

CyclohexanolsHexanolsFatty AlcoholsAlcoholsOrganic ChemicalsDimethylaminesMethylaminesAminesLipids

Study Officials

  • dr aastha raheja

    Maulana Azad Medical College

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
post graduate 1st year student obstetrics and gynecology department

Study Record Dates

First Submitted

December 2, 2016

First Posted

December 21, 2016

Study Start

December 1, 2016

Primary Completion

April 1, 2018

Study Completion

May 1, 2018

Last Updated

December 23, 2016

Record last verified: 2016-12