The Use of Resting State, fMRI and DTI in the Identification of Chronic Pain Conditions

NCT02987933 | Unknown

• 1 other identifier: BSI001
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Resting state fMRI scans of chronic pain sufferers will be compared to those of healthy normals and may be sufficiently different to allow a high level of classification accuracy of whether subjects have chronic pain. In addition, investigators will utilize DTI and a brief activation state using pain rumination to assess whether investigators can reliably find differences between chronic pain sufferers and healthy normals.

Conditions

Chronic Pain

Keywords

Chronic Pain; fMRI; DTI

Outcome Measures

Primary Outcomes (1)

• Functional brain connectivity

  Assessed by fMRI

  6 months

Study Arms (2)

Chronic Pain

Adults, \> 6 months duration, daily pain

Healthy Normals

Age and gender matched controls

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults with daily chronic pain (\> 6 months)

You may qualify if:

• Daily Pain lasting for more than 6 months. Ages eligible for study are between 20 and 70 years.

Sponsors & Collaborators

• Brain Scan Inc.: lead
• State University of New York at Buffalo: collaborator

Study Sites (1)

WNY MRI

Buffalo, New York, 14203, United States

RECRUITING

Related Publications (5)

• Napadow V, LaCount L, Park K, As-Sanie S, Clauw DJ, Harris RE. Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. Arthritis Rheum. 2010 Aug;62(8):2545-55. doi: 10.1002/art.27497.

  PMID: 20506181 BACKGROUND

• Kucyi A, Moayedi M, Weissman-Fogel I, Goldberg MB, Freeman BV, Tenenbaum HC, Davis KD. Enhanced medial prefrontal-default mode network functional connectivity in chronic pain and its association with pain rumination. J Neurosci. 2014 Mar 12;34(11):3969-75. doi: 10.1523/JNEUROSCI.5055-13.2014.

  PMID: 24623774 BACKGROUND

• Baliki MN, Geha PY, Apkarian AV, Chialvo DR. Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. J Neurosci. 2008 Feb 6;28(6):1398-403. doi: 10.1523/JNEUROSCI.4123-07.2008.

  PMID: 18256259 BACKGROUND

• Boeckle M, Schrimpf M, Liegl G, Pieh C. Neural correlates of somatoform disorders from a meta-analytic perspective on neuroimaging studies. Neuroimage Clin. 2016 Apr 10;11:606-613. doi: 10.1016/j.nicl.2016.04.001. eCollection 2016.

  PMID: 27182487 BACKGROUND

• Tagliazucchi E, Balenzuela P, Fraiman D, Chialvo DR. Brain resting state is disrupted in chronic back pain patients. Neurosci Lett. 2010 Nov 12;485(1):26-31. doi: 10.1016/j.neulet.2010.08.053. Epub 2010 Aug 26.

  PMID: 20800649 BACKGROUND

MeSH Terms

Conditions

Chronic Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• David S Wack, Ph.D.

  University at Buffalo: SUNY

  PRINCIPAL INVESTIGATOR

Central Study Contacts

David S Wack, Ph.D.

CONTACT

716-838-5889; dswack@buffalo.edu

David T Corey, Ph.D.

CONTACT

855-822-7226; dcorey@brainscaninc.ca

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 7, 2016
• First Posted: December 9, 2016
• Study Start: November 1, 2016
• Primary Completion: November 1, 2017
• Study Completion: January 1, 2018
• Last Updated: December 9, 2016

Record last verified: 2016-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)