Oral Health for Healthy Cognitive Aging

NCT02986386 | Completed

• 1 other identifier: SOECS-905
• Study Type: interventional
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Oral health is a critical factor of systemic health, although usually forgotten. A potential relation between cognitive deficits and oral diseases has been suggested. Adult cognitive dysfunctions have a high impact, not only economic, but social and in the family environment. Based on anatomical connectivity between the oral cavity and the central nervous system, the proposed study hypothesizes that masticatory function is a relevant determinant of human cognitive health. The restoration of canonical masticatory function and masticatory training could help to delay the development of such conditions. This project will also test if restoring phasic masticatory function improves the execution of cognitive tasks.

Conditions

Malocclusion; Dementia

Keywords

Dental Occlusion; Oral Health; Mastication; Dementia; Psychological health

Outcome Measures

Primary Outcomes (5)

• Change of occlusion units

  Number of teeth occluding with opposing teeth

  Baseline, 6, 12 and 36 months

• Change of cerebral activity

  Functional MRI

  Baseline, 6, 12 and 36 months

• Change of cognitive function

  Verbal fluency

  Baseline, 6, 12 and 36 months

• Change of frame of mind

  Beck test

  Baseline, 6, 12 and 36 months

• Change of resting brain activity

  Electroencephalographic activity

  Baseline, 6, 12 and 36 months

Study Arms (4)

Intervention 1

EXPERIMENTAL

Dental occlusion restoration by placement of dental implants and prosthesis on missing teeth.

Procedure: Dental occlusion restoration

Wait list control 1

OTHER

Group of patients that will be evaluated until they receive the dental occlusion restoration procedure.

Procedure: Dental occlusion restoration

Intervention 2

EXPERIMENTAL

Orthodontic treatment of malocclusion.

Procedure: Orthodontic treatment of malocclusion

Wait list control 2

OTHER

Group of patients that will be evaluated until they receive the orthodontic treatment of malocclusion.

Procedure: Orthodontic treatment of malocclusion

Interventions

Dental occlusion restoration PROCEDURE

Placement of dental implants by surgical intervention followed, after a healing period of 2 months, by fabrication and installation of implant supported dental prosthesis

Intervention 1; Wait list control 1

Orthodontic treatment of malocclusion PROCEDURE

Orthodontic therapy to treat malocclusion

Intervention 2; Wait list control 2

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• For Dental occlusion restoration groups: Need of, at least, two molar teeth replacement in the same quadrant.
• For Orthodontic treatment of malocclusion groups: Class I, II or III malocclusion.

You may not qualify if:

• Psychoactive drug.
• Central nervous system depressor.
• Patients not willing or not able to consent.

Sponsors & Collaborators

• Universidad de Granada: lead

Study Sites (1)

Facultad de Odontología

Granada, Granada, 18071, Spain

Location

Related Publications (3)

• Akazawa Y, Kitamura T, Fujihara Y, Yoshimura Y, Mitome M, Hasegawa T. Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus. Int J Mol Med. 2013 Feb;31(2):307-14. doi: 10.3892/ijmm.2012.1217. Epub 2012 Dec 18.

  PMID: 23254518 BACKGROUND

• Elsig F, Schimmel M, Duvernay E, Giannelli SV, Graf CE, Carlier S, Herrmann FR, Michel JP, Gold G, Zekry D, Muller F. Tooth loss, chewing efficiency and cognitive impairment in geriatric patients. Gerodontology. 2015 Jun;32(2):149-56. doi: 10.1111/ger.12079. Epub 2013 Oct 16.

  PMID: 24128078 BACKGROUND

• Gil-Montoya JA, Ponce G, Sanchez Lara I, Barrios R, Llodra JC, Bravo M. Association of the oral health impact profile with malnutrition risk in Spanish elders. Arch Gerontol Geriatr. 2013 Nov-Dec;57(3):398-402. doi: 10.1016/j.archger.2013.05.002. Epub 2013 Jun 10.

  PMID: 23763956 BACKGROUND

MeSH Terms

Conditions

Malocclusion; Dementia; Bites and Stings; Psychological Well-Being

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Poisoning; Chemically-Induced Disorders; Wounds and Injuries; Personal Satisfaction; Behavior

Study Officials

• Pablo Galindo-Moreno, DDS, PhD

  Universidad de Granada

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 23, 2016
• First Posted: December 8, 2016
• Study Start: November 1, 2016
• Primary Completion: January 1, 2023
• Study Completion: December 1, 2025
• Last Updated: May 12, 2026

Record last verified: 2026-05

Locations

ES (1)