NCT02986386|Completed
Oral Health for Healthy Cognitive Aging
SOECS
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SOECS
Sponsor study identifier
interventional
150
1 country
1
Study Start
November 2016
Actual (reported)Primary Completion
January 2023
Actual (reported)Study Completion
December 2025
Actual (reported)Oral health is a critical factor of systemic health, although usually forgotten. A potential relation between cognitive deficits and oral diseases has been suggested. Adult cognitive dysfunctions have a high impact, not only economic, but social and in the family environment. Based on anatomical connectivity between the oral cavity and the central nervous system, the proposed study hypothesizes that masticatory function is a relevant determinant of human cognitive health. The restoration of canonical masticatory function and masticatory training could help to delay the development of such conditions. This project will also test if restoring phasic masticatory function improves the execution of cognitive tasks.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2025
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 2016
Actual (reported)November 23, 2016
Actual (reported)December 8, 2016
Actual (reported)January 2023
Actual (reported)December 2025
Actual (reported)Change of occlusion units
Number of teeth occluding with opposing teeth
Baseline, 6, 12 and 36 months
Change of cerebral activity
Functional MRI
Baseline, 6, 12 and 36 months
Change of cognitive function
Verbal fluency
Baseline, 6, 12 and 36 months
Change of frame of mind
Beck test
Baseline, 6, 12 and 36 months
Change of resting brain activity
Dental occlusion restoration by placement of dental implants and prosthesis on missing teeth.
Group of patients that will be evaluated until they receive the dental occlusion restoration procedure.
Orthodontic treatment of malocclusion.
Placement of dental implants by surgical intervention followed, after a healing period of 2 months, by fabrication and installation of implant supported dental prosthesis
Orthodontic therapy to treat malocclusion
Facultad de Odontología
Granada, Granada, 18071, Spain
Akazawa Y, Kitamura T, Fujihara Y, Yoshimura Y, Mitome M, Hasegawa T. Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus. Int J Mol Med. 2013 Feb;31(2):307-14. doi: 10.3892/ijmm.2012.1217. Epub 2012 Dec 18.
Elsig F, Schimmel M, Duvernay E, Giannelli SV, Graf CE, Carlier S, Herrmann FR, Michel JP, Gold G, Zekry D, Muller F. Tooth loss, chewing efficiency and cognitive impairment in geriatric patients. Gerodontology. 2015 Jun;32(2):149-56. doi: 10.1111/ger.12079. Epub 2013 Oct 16.
Pablo Galindo-Moreno, DDS, PhD
Universidad de Granada
First Submitted
November 23, 2016
First Posted
December 8, 2016
Study Start
November 2016
Actual (reported)Primary Completion
January 2023
Actual (reported)Electroencephalographic activity
Baseline, 6, 12 and 36 months
Group of patients that will be evaluated until they receive the orthodontic treatment of malocclusion.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Gil-Montoya JA, Ponce G, Sanchez Lara I, Barrios R, Llodra JC, Bravo M. Association of the oral health impact profile with malnutrition risk in Spanish elders. Arch Gerontol Geriatr. 2013 Nov-Dec;57(3):398-402. doi: 10.1016/j.archger.2013.05.002. Epub 2013 Jun 10.
Study Completion
December 2025
Actual (reported)Last Updated
May 12, 2026
Record last verified: 2026-05
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Source: ClinicalTrials.gov.
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