NCT02984150

Brief Summary

This study aim to investigate the influence of intragastrically infused fatty acid on the generalization of responses to reward within the food domain and between financial and sexual domains.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P50-P75 for not_applicable healthy-volunteers

Timeline
Completed

Started Nov 2014

Typical duration for not_applicable healthy-volunteers

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2014

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2016

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2016

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

October 24, 2016

Completed
1 month until next milestone

First Posted

Study publicly available on registry

December 6, 2016

Completed
Last Updated

May 9, 2017

Status Verified

May 1, 2017

Enrollment Period

1.2 years

First QC Date

October 24, 2016

Last Update Submit

May 5, 2017

Conditions

Healthy Volunteers

Outcome Measures

Primary Outcomes (2)

  • progressive ratio task

    Participants click the screens to get candies. The number of clicks will be used as a measurement of eating behavior.

    10min

  • estimation task

    Participants rate the attractiveness of 20 rewarding food pictures, 20 female face pictures on a 1-7 point scale.

    10min

Secondary Outcomes (1)

  • VAS

    10min

Study Arms (2)

fatty acid

EXPERIMENTAL

the nutrient that can be widely found in daily food.

Dietary Supplement: dodecanoic acid

saline

SHAM COMPARATOR

saline

Dietary Supplement: saline

Interventions

dodecanoic acidDIETARY_SUPPLEMENT
Also known as: Lauric acid
fatty acid
salineDIETARY_SUPPLEMENT
saline

Eligibility Criteria

Age17 Years+
Sexmale
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Men, self-reporting as heterosexual
  • Age: Adults (+ 17yr)
  • ≤ BMI ≤ 27

You may not qualify if:

  • Participants must be in good health, both mental and physical. People with one or more of the following self-reported items applicable, are excluded:
  • \. History of or current presence of:
  • Psychiatric disorders (among others, anxiety disorders, somatoform disorders, eating disorders, depression, addiction-related disorders, and the like)
  • Abdominal / Thoracic Surgery (excl appendectomy or cholecystectomy)
  • Neurological, endocrine or gastrointestinal-related disorders
  • Other serious medical conditions.
  • \. Present the presence of:
  • Pain Symptoms
  • Use of medication that affects the function of the gastrointestinal tract and / or the nervous system; psychotropic drugs or pain killers
  • A recent accident or an operation which one has not yet fully recovered.
  • If it is positive answer to any of these criteria, participation will not be possible. These criteria are questioned in advance so that participants do not get unnecessarily turn up.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospitals Leuven, campus Gasthuisberg

Leuven, 3000, Belgium

Location

Related Publications (4)

  • Briers, B., Pandelaere, M. & Warlop, L. (2007). Adding exchange to charity: A reference price explanation. Journal of Economic Psychology, 28, 15-30. doi: 10.1016/j.joep.2005.12.001.

    BACKGROUND

  • Lassman DJ, McKie S, Gregory LJ, Lal S, D'Amato M, Steele I, Varro A, Dockray GJ, Williams SC, Thompson DG. Defining the role of cholecystokinin in the lipid-induced human brain activation matrix. Gastroenterology. 2010 Apr;138(4):1514-24. doi: 10.1053/j.gastro.2009.12.060. Epub 2010 Jan 18.

    PMID: 20080096BACKGROUND

  • Van den Bergh, B., Dewitte, S. & Warlop, L. (2008). Bikinis instigate generalized impatience in intertemporal choice. Journal of Consumer Behavior, 35, 85-97. doi: 10.1086/525505

    BACKGROUND

  • Van Oudenhove L, McKie S, Lassman D, Uddin B, Paine P, Coen S, Gregory L, Tack J, Aziz Q. Fatty acid-induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans. J Clin Invest. 2011 Aug;121(8):3094-9. doi: 10.1172/JCI46380. Epub 2011 Jul 25.

    PMID: 21785220BACKGROUND

MeSH Terms

Interventions

lauric acidSodium Chloride

Intervention Hierarchy (Ancestors)

ChloridesHydrochloric AcidChlorine CompoundsInorganic ChemicalsSodium Compounds

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

October 24, 2016

First Posted

December 6, 2016

Study Start

November 1, 2014

Primary Completion

January 1, 2016

Study Completion

June 1, 2016

Last Updated

May 9, 2017

Record last verified: 2017-05

Data Sharing

IPD Sharing
Will not share

Locations

BE(1)