NCT02979028

Brief Summary

This is a single center, randomized, double-blinded, controlled clinical trial. The purpose of this study is to to determine whether treating by transcutaneous electrical acupoint stimulation (TEAS) during perioperative could alleviate the postoperative complications in patients undergoing artificial joint replacement surgery.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
300

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started May 2017

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 29, 2016

Completed
2 days until next milestone

First Posted

Study publicly available on registry

December 1, 2016

Completed
5 months until next milestone

Study Start

First participant enrolled

May 1, 2017

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2018

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2018

Completed
Last Updated

April 18, 2017

Status Verified

November 1, 2016

Enrollment Period

10 months

First QC Date

November 29, 2016

Last Update Submit

April 15, 2017

Conditions

Keywords

TEAScomplication

Outcome Measures

Primary Outcomes (1)

  • The incidence of postoperative complications

    Participants will be followed for the incidence of postoperative complications

    within 30 days after operation

Secondary Outcomes (3)

  • length of postoperative hospital stay

    an expected average of 1 week

  • Quality of life during 30 days after surgery

    One month

  • ICU transfer rate after operation

    One month

Study Arms (3)

TEAS group

EXPERIMENTAL

Electric stimulation was given through electrode attached to acupoints SP6 and ST36 .TEAS will be administered 30 minutes prior to surgery and continued until the end of the surgery.

Device: TEAS

Sham group

SHAM COMPARATOR

Non-acupoint is located 2cm inward to the specific acupoints.TEAS will be administered 30 minutes prior to surgery and continued until the end of the surgery.

Device: TEAS

Control group

PLACEBO COMPARATOR

Control patients will receive the same treatment without electrical stimulation.

Device: TEAS

Interventions

TEASDEVICE

Transcutaneous electrical acupoint stimulation

Control groupSham groupTEAS group

Eligibility Criteria

Age60 Years - 89 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • ASAⅡ-Ⅲ,elective operation patients
  • No other severe complications history
  • Able to give informed consent

You may not qualify if:

  • Having severe comorbidity resulting in estimated life expectancy \<1 year.
  • Infection at the electroacupuncture site.
  • Suffered from neurologic disorder or impaired mental state
  • Participate in the other clinical trial 3 months before the enrollment
  • No suitable to participate in this experiment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (7)

  • Huddleston JI, Maloney WJ, Wang Y, Verzier N, Hunt DR, Herndon JH. Adverse events after total knee arthroplasty: a national Medicare study. J Arthroplasty. 2009 Sep;24(6 Suppl):95-100. doi: 10.1016/j.arth.2009.05.001. Epub 2009 Jul 4.

    PMID: 19577884BACKGROUND
  • Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, Ray JG. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004 Sep;126(3 Suppl):338S-400S. doi: 10.1378/chest.126.3_suppl.338S.

    PMID: 15383478BACKGROUND
  • Singh JA, Jensen MR, Harmsen WS, Gabriel SE, Lewallen DG. Cardiac and thromboembolic complications and mortality in patients undergoing total hip and total knee arthroplasty. Ann Rheum Dis. 2011 Dec;70(12):2082-8. doi: 10.1136/ard.2010.148726. Epub 2011 Oct 21.

    PMID: 22021865BACKGROUND
  • Krecisz B, Kiec-Swierczynska M, Chomiczewska-Skora D. Allergy to orthopedic metal implants - a prospective study. Int J Occup Med Environ Health. 2012 Sep;25(4):463-9. doi: 10.2478/S13382-012-0029-3. Epub 2012 Dec 3.

    PMID: 23212287BACKGROUND
  • Hou L, Chen C, Xu L, Yin P, Peng W. Electrical stimulation of acupoint combinations against deep venous thrombosis in elderly bedridden patients after major surgery. J Tradit Chin Med. 2013 Apr;33(2):187-93. doi: 10.1016/s0254-6272(13)60123-5.

    PMID: 23789215BACKGROUND
  • Yang L, Yang J, Wang Q, Chen M, Lu Z, Chen S, Xiong L. Cardioprotective effects of electroacupuncture pretreatment on patients undergoing heart valve replacement surgery: a randomized controlled trial. Ann Thorac Surg. 2010 Mar;89(3):781-6. doi: 10.1016/j.athoracsur.2009.12.003.

    PMID: 20172127BACKGROUND
  • Ni X, Xie Y, Wang Q, Zhong H, Chen M, Wang F, Xiong L. Cardioprotective effect of transcutaneous electric acupoint stimulation in the pediatric cardiac patients: a randomized controlled clinical trial. Paediatr Anaesth. 2012 Aug;22(8):805-11. doi: 10.1111/j.1460-9592.2012.03822.x. Epub 2012 Mar 2.

    PMID: 22380768BACKGROUND

Study Officials

  • Zheng Guo

    Second Hospital of Shanxi Medical University

    STUDY CHAIR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
professor

Study Record Dates

First Submitted

November 29, 2016

First Posted

December 1, 2016

Study Start

May 1, 2017

Primary Completion

March 1, 2018

Study Completion

April 1, 2018

Last Updated

April 18, 2017

Record last verified: 2016-11