Pupillometry in Horner's Syndrome

NCT02978079 | Unknown

• 1 other identifier: KEK-Nr. 2016-02151
• Study Type: interventional
• Target: 135
• Locations: 1 country
• Sites: 1

Brief Summary

Horner's syndrome (HS) is a result of interruption of the sympathetic innervation to the eye and ocular adnexa, which can occur due to carotid artery dissection (CAD), along which the sympathetic nerve fibers travel to reach the eye. Dissection of the carotid artery is one of the etiologies for ischemic stroke in young patients. In our current study, we will explore the diagnostic accuracy of automated binocular pupillometry in the diagnosis or HS, and its potential in identifying dissection of the carotid artery in patients of young age who suffer ischemic stroke.

Conditions

Horner's Syndrome; Stroke; Dissection Carotid Artery

Outcome Measures

Primary Outcomes (1)

• Finding of pupillary dilation lag using pupillometry in patients with acute stroke due to carotid artery dissection

  1 day of initial visit

Study Arms (1)

Pupillometry in stroke patients

EXPERIMENTAL

All eligible patients will undergo pupillometry test for the finding of Horner's syndrome

Device: Automated pupillometry

Interventions

Automated pupillometry DEVICE

Automated pupillometry will be performed in patients with acute stroke with the intention of diagnosing Horner's syndrome

Pupillometry in stroke patients

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults 60 years of age or younger
• Acute stroke (less than 72 hours from admission)
• Informed Consent as documented by signature (Appendix Informed Consent Form)
• Ability to understand the study information and consent form

You may not qualify if:

• known history of HS
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
• Medications affecting pupillary response
• History of ocular surgery affecting the pupil

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

Ophthalmology Department, University Hospital Zurich

Zurich, CH-8091, Switzerland

RECRUITING

MeSH Terms

Conditions

Horner Syndrome; Stroke

Condition Hierarchy (Ancestors)

Autonomic Nervous System Diseases; Nervous System Diseases; Cavernous Sinus Syndromes; Brain Diseases; Central Nervous System Diseases; Miosis; Pupil Disorders; Neurologic Manifestations; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Konrad P Weber, MD

  Ophthalmology Department, University Hospital Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 28, 2016
• First Posted: November 30, 2016
• Study Start: February 15, 2017
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2022
• Last Updated: January 11, 2021

Record last verified: 2021-01

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)