Study on the Neurovascular Coupling Function in Patients Undergoing Cardiac Surgery

NCT02977455 | Unknown

• 1 other identifier: 304460568
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

Existing researches show that brain is an organ highly dependent on continuous blood supply. Energy and oxygen required for normal physiological activities in the brain are stably maintained by a neurovascular regulatory mechanism, also known as functional congestion. While under pathological condition such as ischemia, this regulatory mechanism would be impaired and brain function loss and tissue damage occur. During anesthesia in cardiac surgery, inevitable circulatory fluctuations could result in decreasing blood pressure and cerebral blood flow and therefore brain tissue is in ischemia. In this situation the neurovascular regulatory mechanism will function and the brain oxygen saturation also changes based on how this mechanism is influenced. the investigators were devoted to observe how this mechanism was influenced during surgery and how the neural function recovers after surgery so to explore the relationship between them.

Conditions

Neurovascular Coupling Mechanism and Cognitive Function

Outcome Measures

Primary Outcomes (1)

• Thirty of participants with Cognitive function assessment based on "Direction of Chinese Binet Tests (third edition)"

  IQ scores will be used to quantify cognitive function

  6 months

Eligibility Criteria

• Age: 2 Years - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Cardiac surgery patients

You may qualify if:

• Age \<12 years old
• Will take cardiac surgery and general anesthesia
• Cognitive status is normal
• Cardiac function grade Ⅱ-Ⅲ (using the NYHA cardiac function classification)

You may not qualify if:

• Emergency surgery
• ASA-V or VI
• Coagulation disorders,multiple organs dysfunction, endocrine system diseases and severe infectious diseases
• Patients have been installed pacemakers
• Suspected or indeed alcohol, drug abuse history
• Can not cooperate with research, such as the following: language understanding, mental illness, etc.
• Participated in other clinical trials
• Perioperative stroke
• The researchers believe that should not be included in the study

Sponsors & Collaborators

• Xiangya Hospital of Central South University: lead

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 16, 2016
• First Posted: November 30, 2016
• Study Start: October 1, 2016
• Primary Completion: March 1, 2017
• Last Updated: November 30, 2016

Record last verified: 2016-10