Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM

NCT02977390 | Completed

• 1 other identifier: ANE-HS 2013-06
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

This is a pilot study to investigate whether patients at advanced age are fluid responders via a reversible fluid challenge, the passive leg raise test. This will be measured with a non-invasive cardiac output monitor, the LiDCO (LiDCO Hemodynamic monitoring) .

Conditions

Stroke Volume; Cardiovascular System; Fluid Therapy

Outcome Measures

Primary Outcomes (1)

• Assess passive leg raise responsiveness in spontaneously breathing aged patients.

  Stroke volume changes in ml and as per cent change compared to baseline

  Within 1 minute of the intervention

Secondary Outcomes (1)

• Investigate whether there is an association between a positive response to passive leg raise on stroke volume and post spinal anesthesia.

  30 minutes

Study Arms (1)

Passive Leg Raise (PLR)

OTHER

The patient is placed in a 45 degree recumbent position. Stroke volume is measured in ml. Intervention:The patient is placed horizontal and the legs are passively raised to 45 degrees. Measurement:The effect of the PLR on Stroke Volume is measured. Thereafter the patient is repositioned to the initial position and Stroke Volume is measured again.

Other: Passive leg raise

Interventions

Passive leg raise OTHER

By tilting the patient's bed from sitting 45 degrees to supine with legs tilted up 45 degrees we recruit the blood volume in the legs and can measure a reversible fluid challenge on stroke volume.

Passive Leg Raise (PLR)

Eligibility Criteria

• Age: 80 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• patients ≥80 years of age, undergoing elective urologic surgical procedure

You may not qualify if:

• age \<80 years, severe aortic insufficiency, first case of the day on the operation program, unavailability of research personnel and contraindication to Lithium.

Sponsors & Collaborators

• Karolinska Institutet: lead

Study Sites (1)

Karolinska University Hospital

Huddinge, 14186, Sweden

Location

Study Officials

• Sigridur Kalman, Professor

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 22, 2016
• First Posted: November 30, 2016
• Study Start: October 1, 2013
• Primary Completion: January 1, 2015
• Study Completion: January 1, 2015
• Last Updated: December 1, 2016

Record last verified: 2016-11

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)