Artificial Shrinkage for Human Blastocyst Prior Vitrification
AS
Removal of Blastocoel Fluid Before Blastocyst Vitrification by Laser Pulse and Its Effect on Clinical Outcomes
1 other identifier
interventional
100
1 country
1
Brief Summary
Investigators aim to investigate the effect of elimination of blastocoelic fluid by creating a large hole in the zona pellucida at the cellular junction of the trophectoderm cells located far away from the inner cell mass with a laser pulse before vitrification.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Sep 2016
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2016
CompletedFirst Submitted
Initial submission to the registry
November 25, 2016
CompletedFirst Posted
Study publicly available on registry
November 29, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2017
CompletedNovember 29, 2016
November 1, 2016
1.2 years
November 25, 2016
November 28, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Implantation rate
number of intrauterine gestational sacs over the total number of embryos transferred
1 month
Study Arms (2)
Artificial shrinkage
EXPERIMENTALElimination of blastocoelic fluid by creating a large hole in the zona pellucida at the cellular junction of the trophectoderm cells located far away from the inner cell mass with a laser pulse before vitrification.
Without Artificial shrinkage
NO INTERVENTIONVitrify expanded blastocysts.
Interventions
Artificially eliminated blastocoelic fluid before vitrification procedures.
Eligibility Criteria
You may qualify if:
- BMI of ≤ 32
You may not qualify if:
- Non-expanded blastocysts.
- Women who had uterine pathology or abnormality.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Dar AlMaraa Centerlead
- Benha Universitycollaborator
Study Sites (1)
Yasmin Magdi
Banhā, Egypt
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Scientific IVF lab director
Study Record Dates
First Submitted
November 25, 2016
First Posted
November 29, 2016
Study Start
September 1, 2016
Primary Completion
December 1, 2017
Study Completion
December 1, 2017
Last Updated
November 29, 2016
Record last verified: 2016-11