NCT02970136

Brief Summary

The purpose of this research study is to determine the best way to increase screening for cervical cancer, colorectal cancer, HIV, and Hepatitis C among under screened Hispanic, Haitian and African-American individuals in Hialeah, South Dade, and Little Haiti. The investigator will compare home testing led by a community health worker (CHW) versus clinic testing guided by a CHW. Community Health Workers are people who have undergone several weeks of community outreach and health education training. During the study period the participant will continue to receive all of their regular medical care from their regular health care providers. If the participant does not have a health care provider, the Community Health Workers would be able to help in referring the participant for care at a local health care clinic located in their community.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
754

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Apr 2017

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 18, 2016

Completed
3 days until next milestone

First Posted

Study publicly available on registry

November 21, 2016

Completed
5 months until next milestone

Study Start

First participant enrolled

April 11, 2017

Completed
3.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 30, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 30, 2020

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

December 28, 2021

Completed
Last Updated

December 28, 2021

Status Verified

November 1, 2021

Enrollment Period

3.6 years

First QC Date

November 18, 2016

Results QC Date

October 29, 2021

Last Update Submit

November 29, 2021

Conditions

Keywords

Increased Screening UptakeCommunity Health WorkerMedically Underserved

Outcome Measures

Primary Outcomes (1)

  • Percentage of Participants Who Are Screened for All Conditions

    As evaluated by participant self report and completed sampling kits. Female participants are to be screened on 4 conditions: HIV, HCV, Human Papilloma Virus (HPV) and Fecal Immunochemical Testing (FIT). Male participants are to be screened on 3 conditions: HIV, Hepatitis C Virus (HCV) and FIT.

    Baseline

Secondary Outcomes (2)

  • Change in Percentage of Participants Completing Screening Test From Baseline to 6 Months

    Baseline, Up to 6 months

  • Median Number of Screenings Completed

    At baseline and at 6 months

Study Arms (2)

Home Based Screening

EXPERIMENTAL

The participant will be receiving home-based screening tests (OraQuick Swab, OraQuick Fingerstick, Human Papillomavirus (HPV) Self-Sampling Test, Fecal Immunochemical Test) delivered by the community health worker

Device: OraQuick SwabDevice: Fecal Immunochemical TestDevice: OraQuick FingerstickDevice: HPV Self-Sampling TestOther: Home Based Screening Tests

Clinic Based Screening

ACTIVE COMPARATOR

The participant will meet the Community Health Worker and will be navigated to a clinic appointment for standard screening tests

Other: Standard Screening Tests

Interventions

OraQuick for oral fluid HIV antibody testing

Home Based Screening

Fecal Immunochemical stool test specific for human hemoglobin

Home Based Screening

Patients will be tested for Hepatitis C infection using a fingerstick

Home Based Screening

Patients will be navigated to a local health center for standard screening tests

Clinic Based Screening

Patients will be using swab to check for HPV infection

Home Based Screening

Patients will provided screening tests and instructed by Community Health Worker on how to perform home screening tests

Home Based Screening

Eligibility Criteria

Age50 Years - 64 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • live in one of the three target communities
  • self-identify as Haitian, Hispanic and/or Black.
  • be 50-64 years old
  • need at least one of the four recommended screening services as per US Preventive Service Task Force 121 guidelines as follows: never having had a HIV test b) never having had a Hepatitis C Virus (HCV) test c) not having a Pap smear in the last three years d) not having had a colonoscopy in last 10 years and/or stool-based test in the last year.

You may not qualify if:

  • plan to move out of the community during the next six months;
  • current or prior enrollment (5 five years) in any research study that involved screening for these conditions.
  • Are adults unable to consent
  • Are individuals who are not yet adults (infants, children, teenagers)
  • Pregnant women
  • Prisoners

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Miami

Miami, Florida, 33136, United States

Location

Related Publications (1)

  • Carrasquillo O, Seay J, Jhaveri V, Long T, Kenya S, Thomas E, Sussman D, Trevil D, Koru-Sengul T, Kobetz E. Increasing uptake of evidence-based screening services though a community health worker-delivered multimodality program: study protocol for a randomized pragmatic trial. Trials. 2020 Apr 29;21(1):368. doi: 10.1186/s13063-020-4213-7.

MeSH Terms

Conditions

Acquired Immunodeficiency SyndromeHepatitis CColorectal Neoplasms

Condition Hierarchy (Ancestors)

HIV InfectionsBlood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesSlow Virus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System DiseasesHepatitis, Viral, HumanFlaviviridae InfectionsHepatitisLiver DiseasesDigestive System DiseasesIntestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsGastrointestinal DiseasesColonic DiseasesIntestinal DiseasesRectal Diseases

Results Point of Contact

Title
Olveen Carrasquillo
Organization
University of Miami

Study Officials

  • Olveen Carrasquillo, MD

    University of Miami

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
SCREENING
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Medicine and Public Health Sciences

Study Record Dates

First Submitted

November 18, 2016

First Posted

November 21, 2016

Study Start

April 11, 2017

Primary Completion

October 30, 2020

Study Completion

October 30, 2020

Last Updated

December 28, 2021

Results First Posted

December 28, 2021

Record last verified: 2021-11

Data Sharing

IPD Sharing
Will not share

Locations