NSAID Treatment of Patients With Osteoarthritis
BEVAR: Patientspecifik Behandling Ved Artrose - Et "Proof-of-concept"- Kvalitetssikringsstudie
1 other identifier
interventional
162
1 country
1
Brief Summary
The study investigates associations between pre treatment pain intensity and central pain mechanisms on the effect of 8-week treatment of NSAIDs in patients with knee osteoarthritis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jan 2016
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2016
CompletedFirst Submitted
Initial submission to the registry
November 14, 2016
CompletedFirst Posted
Study publicly available on registry
November 18, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2018
CompletedFebruary 22, 2024
February 1, 2024
2 years
November 14, 2016
February 21, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Pain intensity measured on a 10cm visual analog scale
Patients will be asked to rate the pain intensity 8 weeks after treatment on a 10cm visual analog scale (0 indicating no pain, 10 indicating worst imaginable pain
8 weeks after treatment
Study Arms (1)
NSAID treatment
EXPERIMENTAL8 weeks of NSAID treatment
Interventions
NSAIDs are among the most common pain treatments for patients with osteoarthritis.
Eligibility Criteria
You may qualify if:
- Diagnosed Knee Ostoarthritis
You may not qualify if:
- Current ulcer diagnosed by endoscope
- Asthma or other allergic reaction to NSIADs
- Kidney disease
- Myocardial infarction within the last six months
- Severe hyper tension (systolic ≥180mmHg, diastolic ≥110mmHg)
- Severe thrombocytopenia (thrombocyst count \<50x10\^9/l)
- Insufficience lever or kidney function
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Center for Sensory Motor Interaction, Aalborg University
Aalborg East, 9220, Denmark
Related Publications (2)
Giordano R, Arendt-Nielsen L, Hertel E, Olesen AE, Petersen KK. Multifactorial Machine Learning Algorithm Integration of Pain Mechanisms Can Predict the Efficacy of 3-Week NSAID Plus Paracetamol in Patients With Painful Knee Osteoarthritis. Eur J Pain. 2025 Nov;29(10):e70140. doi: 10.1002/ejp.70140.
PMID: 41020650DERIVEDHertel E, Arendt-Nielsen L, Olesen AE, Andersen MS, Petersen KK. Quantitative sensory testing, psychological factors, and quality of life as predictors of current and future pain in patients with knee osteoarthritis. Pain. 2024 Aug 1;165(8):1719-1726. doi: 10.1097/j.pain.0000000000003194. Epub 2024 Feb 20.
PMID: 38381930DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- assistant professor
Study Record Dates
First Submitted
November 14, 2016
First Posted
November 18, 2016
Study Start
January 1, 2016
Primary Completion
January 1, 2018
Study Completion
February 1, 2018
Last Updated
February 22, 2024
Record last verified: 2024-02