Innovation Research of Differentiation and Treatment Methods Based on CHD Phlegm and Blood Stasis Syndrome

NCT02967718 | Unknown DMC

• 1 other identifier: 2014CB542903
• Study Type: observational
• Target: 13,000
• Locations: 1 country
• Sites: 1

Brief Summary

Coronary heart disease is still the major cause of death in China. Chinese medicine plays more and more important role in CHD prevention and treatment. Phlegm and blood stasis are its major pathological basis. Based on that, the investigator aims to evaluate the evolutionary process of CHD phlegm-blood stasis syndrome by large samples, multi-centre, cross-section observation combining with longitudinal tracking on-site survey method so as to guide the clinical treatment of CHD.

Conditions

Coronary Heart Disease

Outcome Measures

Primary Outcomes (1)

• all cause mortality

  6 months

Study Arms (6)

Control group

the healthy patients

Metabolic syndrome group

Include patients who are accordance with diagnostic criteria of metabolic syndrome

CHD stable stage group

Include patients who are accordance with diagnostic criteria of asymptomatic angina, stable angina or stable (more than 1 month) acute coronary syndrome

Acute coronary syndrome group

Include patients who are accordance with diagnostic criteria of unstable angina or non-ST-segment elevated myocardial infarction

PCI or CABG group

Include the patients who will undergo percutaneous coronary intervention of coronary artery bypass grafting

CHD heart failure group

Include the patients who suffered heart failure cause by CHD

Eligibility Criteria

• Age: 35 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy, metabolic or coronary heart disease people, whose age is between 35-85 years old, either female or male, without any inflammation, fever, trauma, burn or operation within 1 week.

You may qualify if:

• Healthy or metabolism syndrome people
• Clinical diagnosis of CHD stable stage or acute coronary disease or CHD heart failure

You may not qualify if:

• Any inflammation, fever, trauma, burn or operation within 1 week
• Obstructive pulmonary disease
• Cerebral vascular disease
• Severe renal or hepatic dysfunction
• Malignant neoplasms
• Hematopoietic system disease
• Sever mental disease

Sponsors & Collaborators

• Jingqing Hu: lead

Study Sites (1)

The First Integrative Hospital of Beijing

Beijin, Beijing Municipality, China

RECRUITING

Related Publications (1)

• Zhang J, Tong H, Jiang L, Hu J. Dietary Patterns Associated With Heat Retention in Blood Vessel Syndrome (HRBVS) in Coronary Heart Disease: A Cross-Sectional Study. Int J Gen Med. 2025 Mar 5;18:1283-1294. doi: 10.2147/IJGM.S510507. eCollection 2025.

  PMID: 40062358 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum sample

MeSH Terms

Conditions

Coronary Disease

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Central Study Contacts

Weiming Xu, Doctor

CONTACT

86-15652608470; dreameng2008@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Director of Institute of Basic Theory of Traditional Chinese Medicine

Study Record Dates

• First Submitted: November 16, 2016
• First Posted: November 18, 2016
• Study Start: September 1, 2016
• Primary Completion: March 1, 2017
• Study Completion: December 1, 2017
• Last Updated: November 22, 2016

Record last verified: 2016-11

Locations

CN (1)