Knee Osteoarthrosis (KOA) in Jordanian Patients: a Phase I Dose-finding Study Using Adipose Tissue Derived Mesenchymal Stem Cells (ATMSC) for Advanced Stage III and IV KOA
Sponsor study identifier
interventional
10
1 country
1
Study Start
January 17, 2017
Actual (reported)Primary Completion
September 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Adipose tissue derived Mesenchymal Stem cells (ATMSC) will be injected in patients diagnosed with Knee osteoarthrosis
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 15, 2016
Actual (reported)November 17, 2016
Actual (reported)January 17, 2017
Actual (reported)September 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Evaluation of the safety and tolerability of the intra articular injection
patients will be monitored for any adverse events resulting from the intraarticular injection of ATMSC
Time Frame: 6 months
Assessment of the efficacy of intra-articular injection of ATMSC
12 months
Intra-articular adipose tissue derived mesenchymal stem cell injection will be given for each patient in 2 doses, 50 million of ATMSC in each dose
Intra-articular adipose tissue derived mesenchymal stem cell injection.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Cell Therapy Center
Amman, 11942, Jordan
Jafar H, Samara O, Shahin D, Daoud F, Al-Hattab D, Samara A, Al Lawama L, Hamdan M, Qubbaj H, Salah B, Awidi A. Intra-articular allogeneic adipose-derived mesenchymal stromal cell injections for stage III knee osteoarthritis: a double-blind placebo-controlled trial with 60-month follow-up. Stem Cells Transl Med. 2026 Apr 27;15(5):szag018. doi: 10.1093/stcltm/szag018.
Abdallah Awidi, MD
Cell Therapy Center
First Submitted
November 15, 2016
First Posted
November 17, 2016
Study Start
January 17, 2017
Actual (reported)Primary Completion
September 2021
Estimated (date passed)Treatment of Knee Arthrosis With Platelet-derived Growth Factors vs. Hyaluronic Acid.
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
April 28, 2021
Record last verified: 2021-04
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Source: ClinicalTrials.gov.
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