China Takayasu Arteritis Registry (CTA Registry)

NCT02964364 | Recruiting DMC

• 1 other identifier: NSFC 30770859
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Takayasu arteritis (TA) is a chronic large-vessel vasculitis that mainly affects the aorta and its major branches. The epidemiology and pathophysiology of TA is still unclear in China, although many studies have been done. Our previous study supporting by National Natural Science Foundation of China indicated the cytokines such as hs-CRP, NT-proBNP and tumor necrosis factor-alpha (TNF-α) can be used to monitor TA activity, and HLA gene alleles were associated with TA in Chinese han population. Further investigations with larger samples are needed to fully understand the a pathophysiology of TA. The purpose of this study is to build a Chinese national registry system for TA to obtain real-world information, such as current status of characteristics, diagnosis, disease activity, the severity of disease, treatment and outcomes of Chinese TA patients. To analysis and development of effective disease monitoring and treatment strategies.

Conditions

TAKAYASU ARTERITIS

Keywords

TAKAYASU ARTERITIS

Outcome Measures

Primary Outcomes (1)

• Mortality of the patients with TA

  All-caused death at 10 years.

  10 years （2016-2026）

Secondary Outcomes (1)

• The rate of the major cardiac and cerebrovascular events

  10 years （2016-2026）

Eligibility Criteria

• Age: 5 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Individuals with TA. Participants will have disease in various stages and of different duration.

You may qualify if:

• Age at disease onset \< 40 years. (Development of symptoms or findings related to Takayasu arteritis at age \<40 years)
• Claudication of extremities. (Development and worsening of fatigue and discomfort in muscles of 1 or more extremity while in use, especially the upper extremities)
• Decreased brachial artery pulse. (Decreased pulsation of 1 or both brachial arteries)
• BP difference \>10 mm Hg. (Difference of \>10 mm Hg in systolic blood pressure between arms)
• Bruit audible on auscultation over 1 or both subclavian arteries or abdominal aorta.
• Arteriogram abnormality. (Arteriographic narrowing or occlusion of the entire aorta, its primary branches, or large arteries in the proximal upper or lower extremities, not due to arteriosclerosis, fibromuscular dysplasia, or similar causes; changes usually focal or segmental)

You may not qualify if:

• Vessel lesions that could be entirely due to atherosclerosis.
• Giant cell arteritis or other infectious forms of large vessel vasculitis.

Sponsors & Collaborators

• Aimin Dang: lead

Study Sites (1)

Fuwai Hospital

Beijing, Beijing Municipality, 100037, China

RECRUITING

MeSH Terms

Conditions

Takayasu Arteritis

Condition Hierarchy (Ancestors)

Aortic Arch Syndromes; Aortic Diseases; Vascular Diseases; Cardiovascular Diseases; Arteritis; Vasculitis; Skin Diseases, Vascular; Skin Diseases; Skin and Connective Tissue Diseases

Central Study Contacts

Aimin Dang, MD,PhD

CONTACT

+8610-88322131; aimindangfw@gmail.com

Naqiang lv, MD,PhD

CONTACT

+8610-88322131; lvnaqiang@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Fuwai Hospital, Chinese Academy of Medical Sciences

Study Record Dates

• First Submitted: August 21, 2016
• First Posted: November 16, 2016
• Study Start: August 1, 2016
• Primary Completion: July 1, 2026
• Study Completion: July 1, 2026
• Last Updated: November 16, 2016

Record last verified: 2016-09

Locations

CN (1)