Mortality in Pediatric Intensive Care Unit

NCT02961153 | Completed DMC

• 1 other identifier: fdpicu-01
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 1

Brief Summary

With the development of national economy and medical technology, patients can extend life rely on high-end medical facilities. At the same time, the continued treatment cannot bring benefits to children, even resulting in poor quality of life of children and bringing high medical costs. This makes the limited medical resources are unreasonable distributed. Research showed that PICU mortality rate halved over ten years ago, but the data did not include death cases who left hospital before death. However, the death number of out-hospital were more than death in-hospital. Therefore, the data cannot actually reflect China's mortality rate of PICU. The reason analysis was limited to the cause of the disease, and does not take the social, economic factors into account. This study include eight PICUs of children's Hospital PICU. Critically ill patients are prospectively studied from death risk factors, admission status, disease diagnosis, severity of illness, analyzing of the risk factors of death from disease diagnosis and death risk factors. In addition, we will illuminate the relationship of death and economic factor, especially for who died out-hospital after withdraw or stop treatment.

Conditions

Intensive Care Units, Pediatric

Outcome Measures

Primary Outcomes (3)

• Pediatric Critical Illness Score（PCIS）

  first 24 hours after admission

• Pediatric Risk of Mortality score (PRISM III)

  24 hours

• Pediatric logistic organ dysfunction (PELOD) score

  24hour

Secondary Outcomes (1)

• all cause mortality

  one year

Interventions

death OTHER

Eligibility Criteria

• Age: 29 Days - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

ALL patients admitted to the PICU of eight study centers

You may qualify if:

• ALL patients admitted to the PICU of eight study centers

You may not qualify if:

• Postoperative monitoring of patients with stable hemodynamics
• PCIS score \>90 and not up to the United States PICU admission standards

Sponsors & Collaborators

• Children's Hospital of Fudan University: lead

Study Sites (1)

Children'S Hosptial of Fuan University

Shanghai, China

Location

MeSH Terms

Interventions

Death Domain

Intervention Hierarchy (Ancestors)

Death Domain Superfamily; Protein Interaction Domains and Motifs; Protein Domains; Protein Structural Elements; Protein Conformation; Molecular Conformation; Molecular Structure; Biochemical Phenomena; Chemical Phenomena

Study Officials

• LU guoping, doctor

  Children's Hhospital of Fudan University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of pediatric Emergency and Critical Care Center. Children's Hospital Fudan University;Director of AHA Training Center for pediatric life support. Children's Hospital Fudan University

Study Record Dates

• First Submitted: October 26, 2016
• First Posted: November 10, 2016
• Study Start: August 1, 2016
• Primary Completion: July 31, 2017
• Study Completion: April 1, 2018
• Last Updated: April 10, 2018

Record last verified: 2018-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)