Evning Exposure to Computer Screen Disrupts Sleep, Attention and Biological Rhythms

NCT02957383 | Completed DMC

• 1 other identifier: 2014068
• Study Type: interventional
• Target: 19
• Locations: 0 countries
• Sites: N/A

Brief Summary

Light exposure is on the rise in recent years. In large part because of unintentional illumination from screens that emit light directly into the eyes. Millions of computers, tablets, televisions, and smart-phones are sold worldwide every month and the usage time of these devices is increasing constantly. Today, people are exposed to ongoing light exposure from these device screens, emitting short wave length (SWL) during day and night hours, whether as active or passive users. In sum, artificial light at night (ALAN) seem to affect human circadian rhythmicity (melatonin and thermoregulation) and sleep, with two major factors. First, wavelength of light, with SWL being most detrimental to sleep and rhythms, when compared to LWL (Brianard et al., 2001). Second, a dose-response relationship exists between increasing light intensity and poorer sleep/circadian rhythms (Brianard et al., 1988; West et al., 2011). Based on existing knowledge, we hypothesize that when compared to long wavelength LWL illumination, short wavelength SWL illumination from computer screen will have a more damaging effect on melatonin (MLT) production and secretion, interfering body temperature regulation and affecting sleep quality, efficiency and sleep architecture. In addition, we hypothesized that intensity of the screen illumination will play another important factor on these outcomes, we assume that high intensity compared to low intensity will have more damaging effect on: melatonin, thermoregulation and sleep.

Conditions

Sleep Disorder

Keywords

Sleep, Melatonin; Circadian Rhythm; Temperature; screen illumination

Outcome Measures

Primary Outcomes (14)

• Body temperature

  Oral body temperature, physiological marker

  12 hours

• Melatonin secretion

  Melatonin - Sulfate Urine ELISA 6-SMT ng/ml, physiological marker

  12 hours

• Epworth Sleepiness Scale (ESS) questionire- Sleepiness

  Epworth Sleepiness Scale (ESS) questionire score- Number

  1 day

• Brief Symptom Inventory (BSI)- questionaire

  Assess the subjects emotional state- number

  1 day

• Karolinska Sleep Questionnaire (KSS)-Subjective sleepiness

  KSS questionaire - number

  1 day

• Attention

  continuous performance test (CPT-III) a computerized attention and concentration test. number

  1hour

• Total Sleep Time

  Total sleep time in minute. physiological marker

  1 night

• sleep efficiency

  Percentage of sleep efficiency , physiological marker

  1 night

• Sleep latency to stage 1

  Tine in minute to sleep stage 1, physiological marker

  1 night

• Sleep latency to stage 2

  Tine in minute to sleep stage 2, physiological marker

  1 night

• Wake% TIB

  Percentage of wake from time in bed, physiological marker

  1 night

• Stage 1% TIB

  Percentage of sleep stage 1 from time in bed, physiological marker

  1 night

• Stage 2% TIB

  Percentage of sleep stage 2 from time in bed, physiological marker

  1 night

• SWS% TIB

  Percentage of sleep stage SWS from time in bed, physiological marker

  1 night

Study Arms (2)

wavelength

EXPERIMENTAL

Wavelength at two levels: short (SWL)-485 nm (13500k) and long (LWL)-620 nm (4250k)

Other: Wavelength; Other: Intensity

intensity

EXPERIMENTAL

Luminance at two levels: low - 80 lux (35mw/cm2) and high - 350 lux (160mw/cm2).

Other: Wavelength; Other: Intensity

Interventions

Wavelength OTHER

wavelength at two levels: short (SWL)-485 nm (13500k) and long (LWL)-620 nm (4250k)

intensity; wavelength

Intensity OTHER

Luminance at two levels: low - 80 lux (35mw/cm2) and high - 350 lux (160mw/cm2

intensity; wavelength

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• regular sleep habits in Pittsburgh Sleep Quality Index (PSQI) questionnaire index\<5 normative sleep-wake cycle type (Horne-Ostberg morningness-eveningness questionnaire) 6-8 hours of sleep, normative sleep patterns, and no sleep/wake schedule.

You may not qualify if:

• participants with ocular damage, such as to their field of vision, color blindness, or impaired functioning of the pupil in reaction to light were excluded.

Sponsors & Collaborators

• Assuta Medical Center: lead

MeSH Terms

Conditions

Sleep Wake Disorders

Condition Hierarchy (Ancestors)

Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• Lilach Kemer, Dr

  Assuta Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. Lilach Kemer

Study Record Dates

• First Submitted: November 3, 2016
• First Posted: November 7, 2016
• Study Start: July 1, 2015
• Primary Completion: March 1, 2016
• Study Completion: August 1, 2016
• Last Updated: November 8, 2016

Record last verified: 2016-11

Data Sharing

• IPD Sharing: Will not share