Genetic Predisposition for Chronic Non-specific Low Back Pain
Backgene
Genetic Predisposition for Reduced Back Muscle Strength and Back Muscle Endurance in Patients With Chronic Non-specific Low Back Pain
1 other identifier
observational
100
1 country
1
Brief Summary
Patients with inflammatory back pain were shown to differ from healthy controls in genotype of the Angiotensin-converting enzyme (ACE), which regulates vasoconstriction/-dilatation. The aim of this study is to investigate whether genetic reduction of muscle perfusion might be a pathophysiological pathway of how genes influence chronic non-specific low back pain (LBP).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Sep 2016
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2016
CompletedFirst Submitted
Initial submission to the registry
October 6, 2016
CompletedFirst Posted
Study publicly available on registry
November 4, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
August 31, 2018
CompletedJanuary 23, 2019
January 1, 2019
2 years
October 6, 2016
January 22, 2019
Conditions
Outcome Measures
Primary Outcomes (2)
Polymorphism ACE Gene
baseline
Polymorphism Tenascin Gene
baseline
Secondary Outcomes (1)
Back muscle endurance in Sorensen test
baseline
Study Arms (2)
Low back pain patients
Low back pain since more than 3 months Age: 18-65 Caucasian race
Controls without low back pain
no low back ain Age: 18-65 Caucasian race
Interventions
observational case-control study
Eligibility Criteria
Patients with chronic low back pain and healthy controls without low back pain.
You may not qualify if:
- Spinal surgery
- Spinal fracture
- Inflammation
- Tumour
- Severe chronic disease which make intensive physical activity impossible (osteoporosis, cardiovascular heart diseases)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Balgrist University Hospital
Zurich, 8008, Switzerland
Related Publications (2)
Vaughan D, Huber-Abel FA, Graber F, Hoppeler H, Fluck M. The angiotensin converting enzyme insertion/deletion polymorphism alters the response of muscle energy supply lines to exercise. Eur J Appl Physiol. 2013 Jul;113(7):1719-29. doi: 10.1007/s00421-012-2583-6. Epub 2013 Feb 9.
PMID: 23397151BACKGROUNDShehab DK, Al-Jarallah KF, Al-Awadhi AM, Al-Herz A, Nahar I, Haider MZ. Association of angiotensin-converting enzyme (ACE) gene insertion-deletion polymorphism with spondylarthropathies. J Biomed Sci. 2008 Jan;15(1):61-7. doi: 10.1007/s11373-007-9203-1. Epub 2007 Aug 23.
PMID: 17713861BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Martin Flück, Professor
Balgrist University Hospital
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 6, 2016
First Posted
November 4, 2016
Study Start
September 1, 2016
Primary Completion
August 31, 2018
Study Completion
August 31, 2018
Last Updated
January 23, 2019
Record last verified: 2019-01
Data Sharing
- IPD Sharing
- Will not share