Evaluation Of Lipid Peroxidation, Oxidative DNA Damage And Total Antioxidant Status In Patients With Periodontitis And Polycystic Ovary Syndrome: A Cross Sectional Study
Sponsor study identifier
observational
88
1 country
1
Study Start
May 2013
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
May 2015
Actual (reported)Study Completion
September 2015
Actual (reported)Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic periodontitis (CP) and to compared healthy individuals. Materials and Methods: A total of 88 women were into four groups each which were consisted of twenty-two subjects. Groups were designed as periodontally and systemically healthy women (PCOS-CP-); periodontally healthy women with polycystic ovary syndrome (PCOS) (PCOS+CP-), systemically healthy women with CP (PCOS-,CP+) and women with PCOS and CP (PCOS+CP+). Serum and salivary samples were obtained, clinical periodontal parameters were recorded. MDA, TAS, 8-OHdG levels were measured as biochemically.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 2015
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 2013
Date type not reportedThis date has not been verified as actual or estimated.
May 2015
Actual (reported)September 2015
Actual (reported)October 28, 2016
Actual (reported)November 3, 2016
Actual (reported)8-OHdG levels (nanogram per mililiter(ng/mL))
by ELISA test
appoximately 2 years
MDA levels (micromole per liter (µmol/L))
by ELISA test
appoximately 2 years
TAS levels (millimolar per liter (mmol /L))
by ELISA test
appoximately 2 years
Plaque Index (PI)
Silnes-Löe Periodondal İndex
appoximately 2 years
Gingival Index (GI)
number of individuals with chronic periodontitis
appoximately 2 years
numberer of individuals with polycystic ovary syndrome
appoximately 2 years
systemically and periodontally healthy participants
systemically healthy participants with CP
PCOS participants with periodontally healthy
PCOS participants with CP
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
All participants were recruited among women at the Department of Obstetrics and Gynecology, School of Medicine, Ataturk University
Department of Periodontics, Faculty of Dentistry, Bezmialem Vakif University
Istanbul, Fatih, 34093, Turkey (Türkiye)
Serum and saliva samples were obtained and stored until biochemical analyses
Nesrin Saruhan, PhD
Eskisehir Osmangazi Üniversitesi
Cenk Fatih Çanakcı, Prof
Ataturk University
Saime Ozbek Sebin, Dr
Ataturk University
Humeyra Canakcı, Dr
Buhara Hastanesi
88 participants (actual enrollment reported by the registry).
First Submitted
October 28, 2016
First Posted
November 3, 2016
Study Start
May 2013
Date type not reportedThis date has not been verified as actual or estimated.
The Secretion of Incretin Hormones in Patients With Polycystic Ovary Syndrome
Löe-Silness Periodontal Index
appoximately 2 years
Bleeding on probing (BOP)
Gİngival Bleeding Index
appoximately 2 years
Clinical attachment level (CAL)
by measuring the distance between the cementoenamel junction and the periodontal pocket base
Patients were seen one time
Probing pocket depth (PD))
distance between free gingival margin and periodontal pocket base by usin periodontal probe
appoximately 2 years
Contact the study team to confirm eligibility.
Metin İngeç, Prof
Ataturk University
Ufuk Sezer, Phd
Özel Klinik
Ebru Saglam, PhD
Saglik Bilimleri Universitesi
Primary Completion
May 2015
Actual (reported)Study Completion
September 2015
Actual (reported)Last Updated
January 18, 2020
Record last verified: 2020-01
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Source: ClinicalTrials.gov.
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