Evaluation of New Diagnostic Methods of Cardio-embolic Related (Atrial Fibrillation) Cerebral Infarction

NCT02948140 | Terminated

• 2 other identifiers: 2016/022016-A00020-51
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to estimate the contribution of abdominal imaging by magnetic resonance Imaging (MRI) and abdominal scanner in the detection of subdiaphragmatic infarction associated to the atrial fibrillation in the cerebral infarction.

Conditions

Stroke

Keywords

Subdiaphragmatic infarction

Outcome Measures

Primary Outcomes (1)

• Number of patients with subdiaphragmatic infarctions detected by abdominal MRI

  14 days

Secondary Outcomes (1)

• Number of patients with subdiaphragmatic infarctions detected by abdominal scanner

  14 days

Study Arms (1)

Stroke

EXPERIMENTAL

Procedure: MRI; Procedure: Abdominal scanner

Interventions

MRI PROCEDURE

Stroke

Abdominal scanner PROCEDURE

Stroke

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient over 18
• Patient having a CHADS-VAsc Score ≥ 2;
• Patient hospitalized for a secondary established ischemic accident in an atrial fibrillation not anticoagulated (INR\<2 and/or receiving antiplatelet (aspirin, clopidogrel)) for less than 14 days;
• Patient affiliated to a national insurance scheme or beneficiary
• Patient having given a written consent

You may not qualify if:

• Patient presenting cognitive disorders incompatible with the planned examinations (MRI / SCANNER).
• Pacemaker or implantable defibrillator, or other contraindication in the MRI (metallic eye brightness, intra cerebral clip).
• Contraindication in injected scanner.
• Current pregnancy

Sponsors & Collaborators

• Hopital Foch: lead

Study Sites (1)

Hôpital Foch

Suresnes, 92150, France

Location

Related Publications (4)

• Slaoui T, Klein IF, Guidoux C, Cabrejo L, Meseguer E, Abboud H, Lavalllee PC, Mazighi M, Labreuche J, Amarenco P. Prevalence of subdiaphragmatic visceral infarction in cardioembolic stroke. Neurology. 2010 Mar 30;74(13):1030-2. doi: 10.1212/WNL.0b013e3181d76aaa. Epub 2010 Mar 3.

  PMID: 20200339 BACKGROUND

• Abboud H, Labreuche J, Gongora-Riverra F, Jaramillo A, Duyckaerts C, Steg PG, Hauw JJ, Amarenco P. Prevalence and determinants of subdiaphragmatic visceral infarction in patients with fatal stroke. Stroke. 2007 May;38(5):1442-6. doi: 10.1161/STROKEAHA.106.476804. Epub 2007 Mar 22.

  PMID: 17379822 BACKGROUND

• Flint AC, Tayal AH. The search for paroxysmal atrial fibrillation in cryptogenic stroke: leave no stone unturned. Neurology. 2013 Apr 23;80(17):1542-3. doi: 10.1212/WNL.0b013e31828f1938. Epub 2013 Mar 27.

  PMID: 23535494 BACKGROUND

• White H, Boden-Albala B, Wang C, Elkind MS, Rundek T, Wright CB, Sacco RL. Ischemic stroke subtype incidence among whites, blacks, and Hispanics: the Northern Manhattan Study. Circulation. 2005 Mar 15;111(10):1327-31. doi: 10.1161/01.CIR.0000157736.19739.D0.

  PMID: 15769776 BACKGROUND

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Bertrand Lapergue, MD

  Hôpital Foch

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 18, 2016
• First Posted: October 28, 2016
• Study Start: June 13, 2016
• Primary Completion: December 1, 2020
• Study Completion: December 1, 2020
• Last Updated: February 15, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)