NCT02945254

Brief Summary

Insufficient and low-quality sleep is a major public health problem that has been linked to motor vehicle crashes, industrial disasters, and medical and other occupational errors. Persons experiencing sleep insufficiency are also more likely to suffer from chronic diseases such as hypertension, diabetes, depression, and obesity, as well as from cancer, increased mortality, and reduced quality of life and productivity. The number of people using sleep-inducing drugs to increase or improve sleep is steadily increasing in the last few decades; however, the side effects of these therapies often outweigh the benefits. A few small trials and anecdotal findings suggest that continuous background (pink or white) noise overnight can improve sleep quality, increase acoustic arousal threshold, and reduce sleep onset latency. In an attempt to find new, alternative solutions to increase sleep quality in people suffering from insomnia, the investigators would like to test the effect of surrounding filtered white noise on sleep onset latency and subjective sleep quality in healthy subjects.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at P25-P50 for phase_1

Timeline
Completed

Started Aug 2016

Shorter than P25 for phase_1

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2016

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

October 25, 2016

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 26, 2016

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2017

Completed
1.3 years until next milestone

Results Posted

Study results publicly available

May 25, 2018

Completed
Last Updated

May 25, 2018

Status Verified

May 1, 2018

Enrollment Period

6 months

First QC Date

October 25, 2016

Results QC Date

March 8, 2018

Last Update Submit

May 24, 2018

Conditions

Keywords

sleep onset latencysleep qualityinsomnia

Outcome Measures

Primary Outcomes (1)

  • Sleep Onset Latency (Mins)

    time from lights out to the first epoch of stage 2 NREM sleep

    1 night

Secondary Outcomes (1)

  • Subjective Sleep Quality (VAS)

    1 night

Study Arms (2)

Background noise

ACTIVE COMPARATOR

Overnight sleep study with filtered white noise

Device: NIghtingale (R) device for filtered white noise (Cambridge Sound Management, Waltham, MA)

Silence

NO INTERVENTION

Overnight sleep study with normal environmental noise

Interventions

Eligibility Criteria

Age21 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Age between 21 and 60

You may not qualify if:

  • Any sleep disorder
  • Use of hypnotics

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sleep Disorders Research Program Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Location

MeSH Terms

Conditions

Sleep Initiation and Maintenance Disorders

Condition Hierarchy (Ancestors)

Sleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System DiseasesMental Disorders

Results Point of Contact

Title
Andrew Wellman
Organization
Brigham and women's Hospital

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
phase 1
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD, PhD

Study Record Dates

First Submitted

October 25, 2016

First Posted

October 26, 2016

Study Start

August 1, 2016

Primary Completion

February 1, 2017

Study Completion

February 1, 2017

Last Updated

May 25, 2018

Results First Posted

May 25, 2018

Record last verified: 2018-05

Data Sharing

IPD Sharing
Will not share

Locations