Carbon Monoxide and Oxidative Stress in Waterpipe Smokers

NCT02937415 | Completed DMC

• 1 other identifier: AtaturkTRH
• Study Type: interventional
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Waterpipe is a tool for smoking tobacco, which is thought to be less harmful than cigarette. Unfortunately, there aren't adequate studies about its harms to health that are threatening the young generation all over the world today. The objective of this study was to show the carbon monoxide (CO) levels in waterpipe smokers' breaths, whether can be used or not to reflect the changes of oxidative stress for this reason to predict harmful effects on the pulmonary functions.

Conditions

Waterpipe Smoking; Oxidative Stress

Keywords

carbon monoxide; oxidative stress; waterpipe smoking; cigarette smoking; pulmonary function test

Outcome Measures

Primary Outcomes (1)

• Breath Carbon Monoxide Level

  Levels of CO in breath will be measured in either waterpipe smokers or control group.

  Up to 4 months

Secondary Outcomes (11)

• A spirometric Test; FEV1 (Forced Expiratory Volume in One Second) Measurement.

  Up to 4 months

• A spirometric Test; FVC (Forced Vital Capacity) Measurement.

  Up to 4 months

• A spirometric Test; FEV1/FVC (Forced Expiratory Volume in One Second/Forced Vital Capacity) Measurement.

  Up to 4 months

• A spirometric Test; PEF (Peak Expiratory Flow) Measurement.

  Up to 4 months

• A spirometric Test; FEF25-75 (Forced Expiratory Flow in 25-75%) Measurement.

  Up to 4 months

Study Arms (2)

Waterpipe smokers group

EXPERIMENTAL

Three waterpipe cafes located in Ankara were visited. 50 waterpipe smokers aged 18-40 years, enrolled in the study and created the working group. At the same time, there were also cigarette smokers among these people. Breath carbon monoxide, pulmonary function tests were performed both before and after smoking waterpipe and parameters of oxidative stress and antioxidant status were measured in blood samples after smoking waterpipe.

Procedure: Breath carbon monoxide; Procedure: Pulmonary function tests.; Procedure: Oxidative stress and antioxidant status.

Control group

ACTIVE COMPARATOR

The control group consisted of 50 people of the same age and sex, who had never smoked neither cigarette nor waterpipe. Breath carbon monoxide, pulmonary function tests were performed and parameters of oxidative stress were measured in blood samples.

Procedure: Breath carbon monoxide; Procedure: Pulmonary function tests.; Procedure: Oxidative stress and antioxidant status.

Interventions

Breath carbon monoxide PROCEDURE

Breath carbon monoxide measurement.

Control group; Waterpipe smokers group

Pulmonary function tests. PROCEDURE

Measurement of lung functions by blowing through a tube which measures flow and volumes of participant's lungs.

Also known as: Spirometry

Control group; Waterpipe smokers group

Oxidative stress and antioxidant status. PROCEDURE

Measurement of parameters of oxidative stress and antioxidant status in blood samples.

Control group; Waterpipe smokers group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants who haven't determined major health problems,
• between ages 18-40.

You may not qualify if:

• Participants who under age 18 and above 40,
• pregnant women,
• individuals who have major health problems

Sponsors & Collaborators

• Ataturk Training and Research Hospital: lead

Related Publications (5)

• Mokdad AH, Warren CW. As if cigarettes were not enough, here comes narghile. A commentary on an article by Yunis et al. in IJPH 52/4. Int J Public Health. 2007;52(5):263-4. doi: 10.1007/s00038-007-0221-6. No abstract available.

  PMID: 18030938 RESULT

• Maziak W. The global epidemic of waterpipe smoking. Addict Behav. 2011 Jan-Feb;36(1-2):1-5. doi: 10.1016/j.addbeh.2010.08.030. Epub 2010 Oct 8.

  PMID: 20888700 RESULT

• Maziak W, Ward KD, Afifi Soweid RA, Eissenberg T. Tobacco smoking using a waterpipe: a re-emerging strain in a global epidemic. Tob Control. 2004 Dec;13(4):327-33. doi: 10.1136/tc.2004.008169.

  PMID: 15564614 RESULT

• Dugas E, Tremblay M, Low NC, Cournoyer D, O'Loughlin J. Water-pipe smoking among North American youths. Pediatrics. 2010 Jun;125(6):1184-9. doi: 10.1542/peds.2009-2335. Epub 2010 May 10.

  PMID: 20457679 RESULT

• Shafagoj YA, Mohammed FI. Levels of maximum end-expiratory carbon monoxide and certain cardiovascular parameters following hubble-bubble smoking. Saudi Med J. 2002 Aug;23(8):953-8.

  PMID: 12235470 RESULT

MeSH Terms

Conditions

Water Pipe Smoking; Cigarette Smoking

Interventions

Respiratory Physiological Phenomena; Oxidative Stress

Condition Hierarchy (Ancestors)

Pipe Smoking; Smoking; Behavior; Tobacco Smoking; Tobacco Use

Intervention Hierarchy (Ancestors)

Circulatory and Respiratory Physiological Phenomena; Metabolism; Stress, Physiological; Physiological Phenomena

Study Officials

• Ozcan Erel, Prof. M.D.

  Ankara Yildirim Beyazit University, Medical School, Director of Biochemistry Department, Ankara, Turkey

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Mukremin Er, MD.

Study Record Dates

• First Submitted: December 19, 2015
• First Posted: October 18, 2016
• Study Start: July 1, 2012
• Primary Completion: December 1, 2012
• Study Completion: January 1, 2013
• Last Updated: October 18, 2016

Record last verified: 2016-10