Genetic Biomarkers of Executive Stress

NCT02933203 | Completed DMC

• 1 other identifier: 35668
• Study Type: observational
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine whether stress predicts telomere length in individuals who hold executive-level positions. Telomeres are the caps at the end of each strand of DNA that may affect how cells age. Subjects will complete an online survey/interview and provide one blood sample or saliva samples. The goal is to understand whether stress predicts genetic markers of longevity.

Conditions

Stress

Outcome Measures

Primary Outcomes (1)

• Telomere Length

  Subjects will come in for 1 visit to give a saliva or blood sample which will be used to measure telomere length.

  1 day

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

100 subjects - individuals who hold executive-level positions. Participants are males and females, 18 or older, may be of any ethnic background. The investigators aim to recruit a diverse sample, reflective of the broader population.

You may qualify if:

• People of either gender \>18 years of age.
• Subject hold executive-level position as defined as meeting the following criteria: having managerial responsibility over an organization or substantial part of an organization and/or having strategic influence over the direction of the organization
• Subject or representative is willing to sign the consent for prior to enrollment into the study, and to participate in all aspects of the study. Prospective subject must give verbal assent if unable to sign written consent.
• Adequate visual acuity to complete questionnaires.

You may not qualify if:

• Subjects will be excluded if they have any of the following medical conditions:
• active heart disease
• acute psychiatric disorder (hospitalized in the past year)
• Subject has a history of cancer (except localized skin cancer without metastases or in situ cervical cancer) within one year prior to screening.
• Subject is pregnant, lactating, or planning to become pregnant during the study period.
• Subject is participating or has participated in another research study within 30 days prior to the screening visit.

Sponsors & Collaborators

• Stanford University: lead

Study Sites (1)

Stanford University

Stanford, California, 94305, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Saliva or blood samples

Study Officials

• Natalie Rasgon, M.D., Ph.D.

  Stanford University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: October 12, 2016
• First Posted: October 14, 2016
• Study Start: October 1, 2015
• Primary Completion: June 1, 2017
• Study Completion: June 1, 2017
• Last Updated: July 21, 2017

Record last verified: 2017-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)