Improving Neuromuscular Monitoring and Reducing Residual Neuromuscular Blockade Via E-learning

NCT02925143 | Completed Results DMC

• 1 other identifier: JLT-NM5
• Study Type: interventional
• Target: 6,525
• Locations: 1 country
• Sites: 1

Brief Summary

To assess the impact of an e-learning course in neuromuscular monitoring on the frequency of application of objective neuromuscular monitoring for assessment of depth of neuromuscular blockade in general anaesthesia and secondarily on the incidence of residual neuromuscular blockade after anesthesia. We will collect data prospectively from 6 Danish anaesthesia departments from the time of intervention, using data from the Anaesthesia Information Management System (AIMS). Baseline data is obtained from another study based on the same data extraction procedure (NCT02914119).

Conditions

Neuromuscular Blockade

Keywords

Residual nerve blockade; Neuromuscular monitoring; Residual curarization; Neuromuscular blocking agents; E-learning; Web based learning

Outcome Measures

Primary Outcomes (2)

• Application of Objective Neuromuscular Monitoring (Acceleromyography) in Cases Receiving a Depolarizing Neuromuscular Blocking Agent (NMBA) (Succinylcholine) (Yes/no)

  Number of Participants Who Received a Depolarizing Neuromuscular Blocking Agent (NMBA) (Succinylcholine) and was Monitored with Objective Neuromuscular Monitoring (Acceleromyography). Data on neuromuscular monitoring is automatically registered in the electronic patient chart when the equipment for acceleromyography is activated.

  in the period from induction of anaesthesia to termination of anaesthesia, usually 2 hours

• Application of Objective Neuromuscular Monitoring (Acceleromyography) in Cases Receiving a Non-depolarizing NMBA (Yes/no)

  Number of Participants Who Received a Non-depolarizing Neuromuscular Blocking Agent (NMBA) and was Monitored with Objective Neuromuscular Monitoring (Acceleromyography). Data on neuromuscular monitoring is automatically registered in the electronic patient chart when the equipment for acceleromyography is activated.

  in the period from induction of anaesthesia to termination of anaesthesia, usually 2 hours

Secondary Outcomes (5)

• Last Recorded Train-of-four (TOF) Ratio Before Tracheal Extubation or Removal of Supraglottic Airway Device in Patients Receiving a Non-depolarizing NMBA

  in the period from induction of anaesthesia to termination of anaesthesia, usually 2 hours]

• Administration of Sugammadex in Cases Receiving a Non-depolarizing NMBA (Yes/no)

  in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 5 hours

• Administration of Neostigmine in Cases Receiving a Non-depolarizing NMBA (Yes/no)

  in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 5 hours

• Administration of More Than One Reversal Agent in Cases Receiving a Non-depolarizing NMBA (Yes/no)

  in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 5 hours

• Time in Minutes From Tracheal Extubation or Removal of Supraglottic Airway Device to Discharge From Post-anaesthesia Care Unit in Cases Involving a Non-depolarizing NMBA

  in the period from induction of anaesthesia to discharge from the post-anaesthesia care unit, usually 180 minutes

Study Arms (1)

E-learning course

EXPERIMENTAL

Other: E-learning course in neuromuscular monitoring

Interventions

E-learning course in neuromuscular monitoring OTHER

An e-learning course designed to assess the challenges and common problems experienced by anesthetists when monitoring the neuromuscular blockade during general anesthesia.

E-learning course

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• Herlev Hospital: lead
• Merck Sharp & Dohme LLC: collaborator

Study Sites (1)

Herlev Hospital

Herlev, Denmark

Location

Related Publications (2)

• Thomsen JLD, Mathiesen O, Hagi-Pedersen D, Skovgaard LT, Ostergaard D, Gatke MR; INVERT collaborator group. Improving neuromuscular monitoring and reducing residual neuromuscular blockade via e-learning: A multicentre interrupted time-series study (INVERT study). Acta Anaesthesiol Scand. 2022 May;66(5):580-588. doi: 10.1111/aas.14038. Epub 2022 Feb 13.

  PMID: 35122234 DERIVED

• Thomsen JLD, Mathiesen O, Hagi-Pedersen D, Skovgaard LT, Ostergaard D, Engbaek J, Gatke MR. Improving Neuromuscular Monitoring and Reducing Residual Neuromuscular Blockade With E-Learning: Protocol for the Multicenter Interrupted Time Series INVERT Study. JMIR Res Protoc. 2017 Oct 6;6(10):e192. doi: 10.2196/resprot.7527.

  PMID: 28986337 DERIVED

Results Point of Contact

• Title: Dr. Jakob Thomsen
• Organization: Herlev Hospital

dr.j@demants.dk

004538683868

Study Officials

• Jakob L Thomsen, MD

  Sponsor principal investigator

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: October 4, 2016
• First Posted: October 5, 2016
• Study Start: November 21, 2016
• Primary Completion: June 30, 2017
• Study Completion: June 30, 2017
• Last Updated: May 18, 2021
• Results First Posted: May 18, 2021

Record last verified: 2021-04

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)