NCT02919397

Brief Summary

The overall aim of this feasibility trial is to assess the effectiveness of a wearable technology and an e-diabetes prevention programme delivered via a smartphone application, including motivational messaging, in reducing weight and increasing physical activity in people at risk of developing type 2 diabetes.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Oct 2016

Typical duration for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 20, 2016

Completed
9 days until next milestone

First Posted

Study publicly available on registry

September 29, 2016

Completed
2 days until next milestone

Study Start

First participant enrolled

October 1, 2016

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 25, 2018

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 12, 2018

Completed
Last Updated

August 9, 2018

Status Verified

March 1, 2018

Enrollment Period

1.6 years

First QC Date

September 20, 2016

Last Update Submit

August 8, 2018

Conditions

Outcome Measures

Primary Outcomes (2)

  • Physical activity (average steps per day)

    Average steps taken per day from 7 days wear measured using the Buddi wearable technology, which will be worn 24 hours per day for 7 days

    7 days

  • Weight (kg)

    Measured in light clothing, without shoes, on the a Class 3 Tanita SC240 weighing digital scale to 0.01 kg for weight

    At 12 month follow-up appointment

Secondary Outcomes (11)

  • HbA1c (mmol/mol)

    At 12 month follow-up appointment

  • Height (cm)

    At 12 month follow-up appointment

  • BMI (kg/m^2)

    At 12 month follow-up appointment

  • Waist circumference (cm)

    At 12 month follow-up appointment

  • Hip circumference (cm)

    At 12 month follow-up appointment

  • +6 more secondary outcomes

Study Arms (2)

Intervention

EXPERIMENTAL

If participants are allocated to the intervention group, participants will receive the wearable technology and access to the smartphone application. Motivational messages based on diabetes prevention programme content, and biofeedback messages based on physical activity data provided via the wearable technology, will be received by participants via the application. The diabetes prevention programme educational material will be available via the application.

Device: Wearable technologyBehavioral: Diabetes Prevention Programme educational materialBehavioral: Motivational messaging

Control

ACTIVE COMPARATOR

If participants are allocated to the control group, participants will receive the wearable technology and will be able to access their activity data via the smartphone application. Participants will also have have access to the diabetes prevention programme educational material via the application. Participants will not receive motivational messages related to the education content or activity data.

Device: Wearable technologyBehavioral: Diabetes Prevention Programme educational material

Interventions

Buddi wearable technology will record activity levels, participants will access activity data through smartphone application

ControlIntervention

Educational material accessed through smartphone application

ControlIntervention

Messages sent via smartphone application

Intervention

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • HbA1c between 42 and 47 mmol/mol
  • BMI≥25 kg/m²
  • Fluent in conversational English
  • Permanent resident in Lambeth, Southwark or Lewisham
  • Ownership of a smartphone (iPhone or Android only) for communication defined as logging on at least once/day to the internet
  • Ambulatory.

You may not qualify if:

  • Known diabetes
  • Pregnancy or planning pregnancy during the duration of the study
  • Severe mental illness (severe depression, psychosis, bipolar affective disorder, dementia, learning difficulties, substance problem use or dependence)
  • Severe physical disability e.g. that would prevent any increased uptake of physical exercise
  • Advanced active disease such as cancer or heart failure
  • Any other condition which requires glucose altering drugs
  • Morbid obesity (BMI ≥50 kg/m²)
  • Current participation in a weight loss programme.
  • When in doubt the investigators will seek the GP opinion and approval.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Staite E, Bayley A, Al-Ozairi E, Stewart K, Hopkins D, Rundle J, Basudev N, Mohamedali Z, Ismail K. A Wearable Technology Delivering a Web-Based Diabetes Prevention Program to People at High Risk of Type 2 Diabetes: Randomized Controlled Trial. JMIR Mhealth Uhealth. 2020 Jul 15;8(7):e15448. doi: 10.2196/15448.

MeSH Terms

Conditions

Glucose Intolerance

Interventions

Wearable Electronic Devices

Condition Hierarchy (Ancestors)

HyperglycemiaGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Electrical Equipment and SuppliesEquipment and Supplies

Study Officials

  • Khalida Ismail

    King's College London

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 20, 2016

First Posted

September 29, 2016

Study Start

October 1, 2016

Primary Completion

May 25, 2018

Study Completion

July 12, 2018

Last Updated

August 9, 2018

Record last verified: 2018-03