Pain Perception in Suicidal Behavior Vulnerability

NCT02915679 | Terminated

• 2 other identifiers: UF 91852013-A01029-36
• Study Type: interventional
• Target: 167
• Locations: 1 country
• Sites: 1

Brief Summary

In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked. The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters. The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts. After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).

Conditions

Major Depressive Episode

Keywords

Suicidal behavior; psychological and social pain; physical pain; pain perception

Outcome Measures

Primary Outcomes (1)

• Pain tolerance reported by the patient

  temperature measured when the subject will perceive as intolerable the pain following a painful stimulation performed using a thermode

  During thermal stimulation

Secondary Outcomes (9)

• Pain intensity reported by the patient

  During thermal stimulation

• Pain threshold reported by the patient

  During thermal stimulation

• Temperature assessed at 4/10 on likert scale

  During thermal stimulation performed at the inclusion

• Kinetics of pain intensity

  During thermal stimulation performed at the inclusion

• Social distress perception assessed by social distress questionnaire

  At V2 (one week maximum after the inclusion)

Study Arms (1)

Study participant

OTHER

All the participants performed blood sample for genetic purpose, psychiatric assessment and pain investigation: * 81 depressed patients admitted after a recent suicidal act (\<8 days) * 81 depressed subjects with a past history of suicidal act (\>1month) * 80 depressed subjects without any personal history of suicidal behaviour

Other: Blood sample for genetic purpose, psychiatric assessment and pain investigation

Interventions

Blood sample for genetic purpose, psychiatric assessment and pain investigation OTHER

All the participant will performed the same evaluation and blood analysis: * A clinical assessment by psychiatrics assessing psychiatric disorder and suicidal behavior * Thermal stimulation for pain assessment * Computer game named Cyberball: test of social exclusion * Self report questionnaire for the assessment of reject sensitivity, relationship style, impulsivity, childhood trauma. * Routine blood sampling

Study participant

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• aged by 18 years old
• came from West Europe, excepted Basque and Sardinian (because of genetics analysis)
• main diagnosis of major depressive episode (DSM V criteria)
• not having take antalgics in the 24 hours before assessment
• received a minimal psychotrope treatment (clinician evaluation)
• Able to understand nature, aims, methodology of the study
• Agree to cooperate in clinical and biological assessment
• Having signed informed consent

You may not qualify if:

• Current diagnosis of manic, hypomanic or alcohol dependance or substance abuse in the last 6 months, or diagnosis of schizophrenia or schizoaffective disorder in his lifetime
• Current algic and chronic neurologic disease
• Current or actual treatment by tricyclic antidepressant and Serotonin and norepinephrine reuptake inhibitors(SNRIs)
• Pregnancy
• Patients on protective measure

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

Montpellier Hospital University

Montpellier, 34295, France

Location

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 1, 2016
• First Posted: September 27, 2016
• Study Start: June 17, 2015
• Primary Completion: May 6, 2021
• Study Completion: May 6, 2021
• Last Updated: January 11, 2022

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)