NCT02909387

Brief Summary

Evaluate the efficacy of Project UPLIFT for reducing symptoms of depression and anxiety among African Americans at immediate posttest and after 3 months.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
82

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2016

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 8, 2016

Completed
11 days until next milestone

First Submitted

Initial submission to the registry

September 19, 2016

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 21, 2016

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2019

Completed
Last Updated

June 23, 2020

Status Verified

June 1, 2020

Enrollment Period

3.1 years

First QC Date

September 19, 2016

Last Update Submit

June 22, 2020

Conditions

Keywords

EpilepsySeizure Disorder

Outcome Measures

Primary Outcomes (2)

  • Modified Beck Depression Inventory

    Measure of depressive symptoms over previous two weeks.

    Post intervention (8 weeks)

  • Beck Anxiety Inventory

    Measure of anxiety symptoms over previous week.

    Post intervention (8 weeks)

Secondary Outcomes (2)

  • Modified Beck Depression Inventory

    3-months Post Intervention

  • Beck Anxiety Inventory

    3-months Post intervention

Study Arms (2)

Stratum A

EXPERIMENTAL

This group will be the first to receive the Project UPLIFT intervention, a distance-delivered mindfulness-based cognitive therapy intervention. The intervention is conducted by phone for one hour once a week for 8 weeks.

Behavioral: Project UPLIFT

Stratum B

ACTIVE COMPARATOR

This group will also receive the Project UPLIFT intervention at crossover, after a 10-week waiting period.

Behavioral: Project UPLIFT

Interventions

Project UPLIFTBEHAVIORAL

UPLIFT is an 8-week distance-delivered mindfulness-based cognitive therapy intervention.

Also known as: UPLIFT
Stratum AStratum B

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Identify as African American or Black;
  • Diagnosed by a healthcare provider with epilepsy or seizure disorder at least 3 months ago;
  • Is mildly to moderately depressed or mildly to moderately anxious as determined by the PHQ-4;
  • Willing to be audio-recorded during UPLIFT sessions

You may not qualify if:

  • Reports suicidal ideation within the past month

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Morehouse School of Medicine

Atlanta, Georgia, 30310-1495, United States

Location

MeSH Terms

Conditions

EpilepsyDepressionAnxiety Disorders

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesBehavioral SymptomsBehaviorMental Disorders

Study Officials

  • Rakale C Quarells, PhD

    Morehouse School of Medicine

    PRINCIPAL INVESTIGATOR
  • Nancy Thompson, PhD, MPH

    Emory University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

September 19, 2016

First Posted

September 21, 2016

Study Start

September 8, 2016

Primary Completion

September 30, 2019

Study Completion

September 30, 2019

Last Updated

June 23, 2020

Record last verified: 2020-06

Data Sharing

IPD Sharing
Will share

De-identified participant data will be shared with the Managing Epilepsy Well Network (MEW) database.

Shared Documents
STUDY PROTOCOL, ICF
Time Frame
Data will be made available by December 2019. Data will remain with the MEW Network database indefinitely.
Access Criteria
Access to data will be through the MEW Network database steering board.

Locations