Clinical Database Associated With a Biological Banking Accessible to Initiate Epidemiological and Translational Collaborative Researches in Kidney Transplantation
DIVAT
The French DIVAT: a Clinical Database Associated With a Biological Banking Accessible to Initiate Epidemiological and Translational Collaborative Researches in Kidney Transplantation
1 other identifier
observational
30,000
1 country
8
Brief Summary
The French DIVAT (standing for Données Informatisées et VAlidées en Transplantation in french, and in English "Computerized and VAlidated Data in Transplantation" ) cohort was Kicked off in 1994 by the Transplantation Urology Nephrology Institute of the Nantes University Hospital in France. The primary objective of this multicenter computerized database was to enable prospective clinical and epidemiological research studies concerning kidney transplant recipients, particularly focusing on mid- and long-term clinical outcomes, therapeutic strategies and public health issues. The patient-case system of the DIVAT cohort allows the monitoring of medical records of all patient-specific and allograft-specific data, including bio-banking since 2005. Data are collected from the date of transplantation until the graft failure, at each scheduled outpatient visit or hospital admission motivating by a new clinical, therapeutical or biological expression. The DIVAT cohort contains information on more than 11000 transplant recipients between 1994 and today, issued from 8 French university hospitals centers (the DIVAT Network is organized by a consortium agreement). 18% of all patients underwent retransplantation and 11% of all kidney transplants originated from living donors. The DIVAT network heavily works to ensure a high-quality data collection with the aim of exploring adequately the complex post-transplantation process. The Divat network encourage collaborations and enables interested researchers to submit a research project by completing a request form available on the DIVAT website (http://www.divat.fr/en) describing the context, objectives and design of the study
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 1994
Longer than P75 for all trials
8 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 1994
CompletedFirst Submitted
Initial submission to the registry
September 9, 2016
CompletedFirst Posted
Study publicly available on registry
September 14, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2050
ExpectedStudy Completion
Last participant's last visit for all outcomes
January 1, 2050
September 15, 2016
September 1, 2016
56 years
September 9, 2016
September 14, 2016
Conditions
Outcome Measures
Primary Outcomes (3)
Proportion of participants with Overall Survival
2 years
Proportion of participants with Overall Survival
4 years
Proportion of participants with Overall Survival
6 years
Secondary Outcomes (2)
expansion of effector memory CD8+ T cells dosage
1 year
expansion of effector memory CD8+ T cells dosage
6 years
Study Arms (1)
patients with kidney transplantations
patients with kidney transplantations
Interventions
Eligibility Criteria
Eight French transplantation centers participate to the DIVAT network: Nantes, Paris Necker, Nancy and Montpellier since 1994, Toulouse since 1997, Lyon since 2006, and Paris Saint-Louis and Nice that joined the network since 2013. All patients over the age of 18 years, who received a renal transplant, are included. No other particular inclusion criteria exist.
You may qualify if:
- over the age of 18 years
- with renal transplant
You may not qualify if:
- minor
- pediatric transplantation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (8)
Docteur Buron
Lyon, 69002, France
Professeur Mourad
Montpellier, 34295, France
Professeur Kessler
Nancy, 54035, France
Professeur Ladriere
Nancy, 54035, France
Pr Cassuto
Nice, 06003, France
Professeur Kreis
Paris, 75184, France
Professeur Legendre
Paris, 75184, France
Professeur Rostaing
Toulouse, 31400, France
Related Publications (2)
Choisy C, Foucher Y, Masset C, Maanaoui M, Lenain R, Rostaing L, Jouve T, Le Quintrec M, Serre JE, Morelon E, Charmetant X, Ladriere M, Girerd S, Sicard A, Gosset C, Mariat C, Claisse G, Giral M, Dantan E; DIVAT Consortium. Identification of Donor-recipient Interactions for a Relative Appraisal of Kidney Graft Marginality: A French Multicentric Cohort-based Study. Transplantation. 2025 Dec 1;109(12):e708-e717. doi: 10.1097/TP.0000000000005464. Epub 2025 Jul 14.
PMID: 40653616DERIVEDDanger R, Le Berre L, Cadoux M, Kerleau C, Papuchon E, Mai HL, Nguyen TV, Guerif P, Morelon E, Thaunat O, Legendre C, Anglicheau D, Lefaucheur C, Couzi L, Del Bello A, Kamar N, Le Quintrec M, Goutaudier V, Renaudin K, Giral M, Brouard S; DIVAT Consortium. Subclinical rejection-free diagnostic after kidney transplantation using blood gene expression. Kidney Int. 2023 Jun;103(6):1167-1179. doi: 10.1016/j.kint.2023.03.019. Epub 2023 Mar 27.
PMID: 36990211DERIVED
Biospecimen
peripheral blood cells, serum, plasma, urine, m-RNA, and DNA of recipients and donors
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Magali Giral, PU-PH
Nantes Universuty Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 30 Years
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 9, 2016
First Posted
September 14, 2016
Study Start
January 1, 1994
Primary Completion (Estimated)
January 1, 2050
Study Completion (Estimated)
January 1, 2050
Last Updated
September 15, 2016
Record last verified: 2016-09