Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing

NCT02898675 | Completed DMC

• 1 other identifier: BAP-2011300
• Study Type: interventional
• Target: 26
• Locations: 0 countries
• Sites: N/A

Brief Summary

Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.

Conditions

Chronic Periodontitis

Outcome Measures

Primary Outcomes (1)

• Level of Growth Factor

  Change from baseline growth factors levels of GCF at 6 weeks were measured by periopaper

  6 weeks

Secondary Outcomes (2)

• Alteration of Clinical Attachment Level

  9 month

• Alteration of Periodontal Pocket Depth

  9 month

Study Arms (2)

Platelet Rich Fibrine

EXPERIMENTAL

Platelet Rich Fibrine was applied with open flap debridement in test group.

Device: Platelet rich fibrine

Open Flap Debridement

ACTIVE COMPARATOR

Platelet Rich Fibrin was not applied to control groups. Only open flap debridement was applied to control groups.

Device: Open Flap Debridement

Interventions

Platelet rich fibrine DEVICE

Platelet rich fibrin increases the growth factors. So it was applied for treatment of periodontal bone loss.

Platelet Rich Fibrine

Open Flap Debridement DEVICE

Only open flap debridement treatment the bone loss limitedly

Open Flap Debridement

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with CP who had pocket depth ≤ 5 mm and at least two area (grouped as Control and PRF) with horizontal bone loss after initial treatment

You may not qualify if:

• The subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months

Sponsors & Collaborators

• Ataturk University: lead

Related Publications (2)

• Pradeep AR, Shetty SK, Garg G, Pai S. Clinical effectiveness of autologous platelet-rich plasma and Peptide-enhanced bone graft in the treatment of intrabony defects. J Periodontol. 2009 Jan;80(1):62-71. doi: 10.1902/jop.2009.080214.

  PMID: 19228091 BACKGROUND

• Arabaci T, Kose O, Albayrak M, Cicek Y, Kizildag A. Advantages of Autologous Platelet-Rich Fibrin Membrane on Gingival Crevicular Fluid Growth Factor Levels and Periodontal Healing: A Randomized Split-Mouth Clinical Study. J Periodontol. 2017 Aug;88(8):771-777. doi: 10.1902/jop.2017.160485. Epub 2017 Apr 28.

  PMID: 28452623 DERIVED

MeSH Terms

Conditions

Chronic Periodontitis

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Yasin ÇİÇEK

  Adiyaman University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Associate Professor

Study Record Dates

• First Submitted: August 24, 2016
• First Posted: September 13, 2016
• Study Start: October 1, 2014
• Primary Completion: June 1, 2015
• Study Completion: May 1, 2016
• Last Updated: September 13, 2016

Record last verified: 2016-08