Conditions

Cataract Low Tension Glaucoma Ocular Hypertension Primary Open Angle Glaucoma

Outcome Measures

Primary Outcomes (1)

Change in Intraocular Pressure
Trends in 24 hr IOP will be assessed using the Triggerfish contact lens system. Subjects will wear the lens on the surgical eye before and after surgery. Intraday and nocturnal trends will be analyzed. Additionally, ocular biometric measurements will be acquired and used in conjunction with the Triggerfish lens to develop a conversion factor for Triggerfish measurements (mV Eq) to intraocular pressure measurements (mmHg).
7-10 days before surgery, 6-8 weeks post-operatively

Secondary Outcomes (3)

Change in Optic Nerve Blood Flow
7-10 days before surgery, 6-8 weeks post-operatively
Percent change in Retinal Oxygen Saturation
7-10 days before surgery, 6-8 weeks post-operatively
Change in Ocular Perfusion Pressure
7-10 days before surgery, 6-8 weeks post-operatively

Study Arms (3)

Cataract Surgery Only

Twenty-five participants with mild or moderate open angle glaucoma (OAG) controlled by medication with a visually significant cataract that meets clinical criteria for cataract surgery will be recruited from the glaucoma clinics at the UNC Kittner Eye Center. Patients who are consented for cataract surgery only (Group 1) will be recruited to this group. Each procedure will be completed in a standardized fashion with standardization of the post-operative medications. An effort will be made to gender and age match each surgical group as well as provide reasonable racial and ethnic diversity.

Cataract Surgery with iStent

Twenty-five participants with mild or moderate open angle glaucoma (OAG) that meets clinical criteria for cataract surgery with implantation of an iStent trabecular micro-bypass shunt will be recruited from the glaucoma clinics at the UNC Kittner Eye Center. Patients who are consented for cataract surgery with iStent (Glaukos Corp., Laguna Hills, CA) implantation (Group 2) will be recruited to this group. Each procedure will be completed in a standardized fashion with standardization of the post-operative medications. An effort will be made to gender and age match each surgical group as well as provide reasonable racial and ethnic diversity.

Glaucoma Drainage Device

Twenty-five participants with moderate or severe open angle glaucoma (OAG) that meets clinical criteria for implantation of a glaucoma drainage device (Group 3) will be recruited from the glaucoma clinics at the UNC Kittner Eye Center. Patients who are consented for implantation of a glaucoma drainage device (Group 3) will be recruited to this group. There will be 25 participants in each of the groups. Each procedure will be completed in a standardized fashion with standardization of the post-operative medications. An effort will be made to gender and age match each surgical group as well as provide reasonable racial and ethnic diversity.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Participants who are clinically indicated and already scheduled to undergo one of the following surgical interventions: i) phacoemulsification with intraocular lens implantation, ii) phacoemulsification with intraocular lens and iStent implantation, and iii) glaucoma drainage device (GDD) implantation will be recruited from the glaucoma clinics of the University of North Carolina (UNC) Kittner Eye Center. Patients, 18 - 99, male and female, from every race and ethnicity will be recruited to participate.

You may qualify if:

Sponsors & Collaborators

University of North Carolina, Chapel Hill
Otherlead
American Glaucoma Society
Othercollaborator
National Eye Institute (NEI)

Study Sites (1)

UNC Kittner Eye Center

Chapel Hill, North Carolina, 27517, United States

MeSH Terms

Conditions

Glaucoma, Open-AngleLow Tension GlaucomaCataractOcular Hypertension

Condition Hierarchy (Ancestors)

GlaucomaEye DiseasesOptic Nerve DiseasesLens Diseases

Study Officials

O'Rese J Knight, MD
Unverisity of North Carolina - Chapel Hill
PRINCIPAL INVESTIGATOR

Study Stopped

Assessing Ocular Hemodynamic Response to Surgical Intervention in Glaucoma

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (3)

Study Arms (3)

Cataract Surgery Only

Cataract Surgery with iStent

Glaucoma Drainage Device

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (3)

Study Arms (3)

Cataract Surgery Only

Cataract Surgery with iStent

Glaucoma Drainage Device

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations