Anterior Temporal Epilepsy Neuropsychological Assessment of Faces

NCT02888925 | Unknown

• 1 other identifier: 2013-A00515-40
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose is to evaluate neuropsychological effects of anterior temporal epilepsy in face perception by comparison of performances of epileptic patients and control individuals, sex-, age- and socio-educational level-matched. Secondary purposes are to prospectively evaluate neuropsychological impact of anterior temporal lobectomy performed for surgical treatment of anterior temporal epilepsy on face perception (exploratory study).

Conditions

Anterior Temporal Epilepsy; Anterior Temporal Lobectomy; Face Perception

Outcome Measures

Primary Outcomes (1)

• Scores obtained with Benton test by patients with anterior temporal epilepsy and matched control individuals

  day 0

Secondary Outcomes (2)

• Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals)

  day 0 and after 12 to 18 months

• Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals)

  day 0 and after 24 to 30 months

Study Arms (2)

Epilepsy

OTHER

Patients do face specific tests during conventional pre-lobectomy intercritical assessment hospitalization (inclusion, day 0) and after 6 and 18 months from anterior temporal lobectomy

Other: Mooney test; Other: Benton Face Recognition test; Other: Face inversion effect test; Other: Face composite effect test; Other: Cambridge Face Memory Test; Other: Matching different view test; Other: Memorizing and recognition of new faces test; Other: Memorizing and recognition of new objects test; Other: Recognition of celebrities and access to semantic information test; Procedure: Lobectomy

Control

OTHER

Control individuals do face specific tests during inclusion visit (day 0) and after X months (X = time from day 0 and lobectomy of matched patient + 6 months)

Other: Mooney test; Other: Benton Face Recognition test; Other: Face inversion effect test; Other: Face composite effect test; Other: Cambridge Face Memory Test; Other: Matching different view test; Other: Memorizing and recognition of new faces test; Other: Memorizing and recognition of new objects test; Other: Recognition of celebrities and access to semantic information test

Interventions

Mooney test OTHER

Control; Epilepsy

Benton Face Recognition test OTHER

Control; Epilepsy

Face inversion effect test OTHER

Control; Epilepsy

Face composite effect test OTHER

Control; Epilepsy

Cambridge Face Memory Test OTHER

Control; Epilepsy

Matching different view test OTHER

Control; Epilepsy

Memorizing and recognition of new faces test OTHER

Control; Epilepsy

Memorizing and recognition of new objects test OTHER

Control; Epilepsy

Recognition of celebrities and access to semantic information test OTHER

Control; Epilepsy

Lobectomy PROCEDURE

In patients with anterior temporal epilepsy, at 6 to 12 months after inclusion, depending on surgery decision taken after pre-surgery conventional intercritical assessment

Epilepsy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ALL:
• Informed consent
• Affiliation to social security
• Preliminary medical examination
• PATIENTS WITH EPILEPSY:
• Symptomatic drug-resistant anterior temporal epilepsy (confirmed with video-electroencephalography and magnetic resonance imaging and if necessary intracerebral SEEG exploration)
• Patient needing anterior temporal lobectomy and undergoing pre-surgery conventional intercritical assessment for surgery decision
• Nonverbal IQ ≥ 70 (WAIS-IV)
• At least 6 successful VOSP tests (perception test)

You may not qualify if:

• ALL:
• persons under legal protection or incapable to consent
• Persons deprived of liberty by juridical or administrative decision
• PATIENTS WITH EPILEPSY:
• \- Sever visual disorders of neurological or ophthalmological origin
• CONTROL INDIVIDUALS:
• Psychiatric or neurological disorders
• Important ophthalmological disorders

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

Service de Neurologie, Hôpital Central, CHU de Nancy

Nancy, France

Location

MeSH Terms

Interventions

Anterior Temporal Lobectomy

Intervention Hierarchy (Ancestors)

Surgical Procedures, Operative; Neurosurgical Procedures

Study Officials

• Louis Maillard

  Service de Neurologie, Hôpital Central, CHU de Nancy, France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 31, 2016
• First Posted: September 5, 2016
• Study Start: August 1, 2013
• Primary Completion: September 1, 2017
• Study Completion: March 1, 2020
• Last Updated: July 24, 2019

Record last verified: 2019-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)