FTO rs9939609 and PPARy rs1801282 Polymorphisms in Mexican Adolescents

NCT02886013 | Completed

• 1 other identifier: 2016-03
• Study Type: observational
• Target: 71
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background and Aims: The presence of the FTO rs9939609 and PPARy rs1801282 polymorphisms suggests changes in energy metabolism; this variation may be responsible for the development of various diseases including obesity. The aim of this study was to identify the presence of these polymorphisms in Mexican adolescents with overweight and obesity at high risk for developing diabetes. Methods and Results: This was a descriptive cross-sectional study, where 71 healthy adolescents (average age of 16) were included. Anthropometric measurements, Body mass index, as well as the determination of glucose, insulin and HOMA index were calculated from all the patients. The FTO rs9939609 and PPARy rs1801282 polymorphisms were determined by real-time PCR.

Conditions

Metabolic Syndrome; Insulin Resistance

Keywords

prevalence

Outcome Measures

Primary Outcomes (1)

• Prevalence of the FTO rs9939609 and PPARy rs1801282 polymorphisms.

  The aim of this study was to identify the presence of these polymorphisms in Mexican adolescents with overweight and obesity at high risk for developing diabetes.

  up to 24 months.

Study Arms (1)

Mexican adolescents

Students without known disease, between 14 and 18 years from the "Lic. Adolfo Lopez Mateos" Preparatory school of the Autonomous University of the State of Mexico (UAEMex).

Eligibility Criteria

• Age: 14 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Mexican adolescents with overweight and obesity at high risk for developing diabetes.

You may qualify if:

• Students without known disease, between 14 and 18 years from the "Lic. Adolfo Lopez Mateos" Preparatory school of the Autonomous University of the State of Mexico (UAEMex).

You may not qualify if:

• Those with a history of smoking, pregnancy or diagnosed with a chronic diseases.

Sponsors & Collaborators

• Asociación Científica Latina A.C.: lead

Biospecimen

Retention: SAMPLES WITH DNA

3 mL of venous blood (Vacutainer tubes) were taken in fasting. A sample remained frozen at -70°C (900 series Thermo Scientific) until DNA extraction. Genotyping DNA extraction was performed in the Magna Pure LC 2.0 Instrument (Roche, Germany) using the MagNA Pure LC DNA Isolation Kit 1 (Roche, Germany).

MeSH Terms

Conditions

Metabolic Syndrome; Insulin Resistance

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• María del Socorro Camarillo Romero, PhD.

  Autonomous University of the State of Mexico

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: August 21, 2016
• First Posted: September 1, 2016
• Study Start: January 1, 2013
• Primary Completion: August 1, 2014
• Study Completion: August 1, 2015
• Last Updated: September 1, 2016

Record last verified: 2016-08

Data Sharing

• IPD Sharing: Will not share