Emotions Analysis in Patients With Chronic Phase of Stroke Basal Ganglia

NCT02884882 | Terminated

• 1 other identifier: KALISS RB10.077
• Study Type: interventional
• Target: 149
• Locations: 1 country
• Sites: 1

Brief Summary

Compare the emotional experience of patients with focal lesions of the basal ganglia by ischemic or hemorrhagic damage and healthy participants. These anomalies will be highlighted by neuropsychological and electrophysiological assessments.

Conditions

Stroke Basal Ganglia

Keywords

Stroke Basal Ganglia; Emotional change

Outcome Measures

Primary Outcomes (1)

• The emotional experience

  The emotional response will be compared between patients with focal lesion cores by ischemic or hemorrhagic reached that of healthy participants. Score (from 1 to 10) rated the felt for each target emotions for the following 6 dimensions: joy, sadness, fear, disgust, anger, no emotion, after the presentation of short sequences of standardized films. Six films are presented, each after a relaxation period after which the basal score is measured.

  Baseline

Secondary Outcomes (1)

• The recognition of facial expressions

  Baseline

Study Arms (2)

Emotional induction in stroke population

OTHER

Six films are presented, each after a relaxation period after which the basal score is measured.

Other: Emotional induction

Emotional induction in healthy volunteers

PLACEBO COMPARATOR

Six films are presented, each after a relaxation period after which the basal score is measured.

Other: Emotional induction

Interventions

Emotional induction OTHER

Score (from 1 to 10) rated the felt for each target emotions for the following 6 dimensions: joy, sadness, fear, disgust, anger, no emotion, after the presentation of short sequences of standardized films.

Emotional induction in healthy volunteers; Emotional induction in stroke population

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• For cases :
• right-handed patient
• ischemic or hemorrhagic stroke older than 3 months with single lesion preferably less than 20 mm in diameter affecting the basal ganglia and sparing cortex
• For participants control : right-handed patient

You may not qualify if:

• For cases : severe aphasia - Prosopagnosia apperceptive - cerebral neurological pathology associated history, especially dementia - History of depression and psychiatric disorders treated - another stroke vascular territory than that for which the patient is included - diffuse lesions of the white matter Fazekas a score of\> 2 (periventricular or subcortical) - Contraindications to MRI
• For participants control : No history neurosurgical - No history of head trauma with loss of consciousness - not known neurological disease - not known psychiatric illness - No psychotropic treatment

Sponsors & Collaborators

• University Hospital, Brest: lead

Study Sites (1)

Centre Hospitalier Régional Universitaire de Brest

Brest, 29200, France

Location

Study Officials

• Serge TIMSIT

  Centre Hospitalier Régional de Brest

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 26, 2016
• First Posted: August 31, 2016
• Study Start: December 1, 2011
• Primary Completion: April 1, 2018
• Study Completion: April 1, 2018
• Last Updated: November 28, 2018

Record last verified: 2018-11

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)