Success of Inferior Alveolar Nerve Block in Women Taking Selective Serotonin Reuptake Inhibitors

NCT02884596 | Completed DMC

• 1 other identifier: 394867
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the success of inferior alveolar nerve block (IANB) for mandibular molars with irreversible pulpitis in women under treatment with selective serotonin reuptake inhibitors (SSRIs).

Conditions

Local Anesthesia

Keywords

Inferior alveolar nerve block; irreversible pulpitis; selective serotonin reuptake inhibitor antidepressants

Outcome Measures

Primary Outcomes (1)

• the success rate of the IAN block

  taking any type of SSRI for at least six weeks prior to the study

Interventions

selective serotonin reuptake inhibitor DRUG

Taking any type of SSRI medicaments

Also known as: SSRI

Eligibility Criteria

• Age: 20 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Seventy adult women patients participated in this study and were assigned to either SSRIs users or SSRIs non-users groups. SSRIs users were 45 women who take SSRIs referred for endodontic treatment from a psychiatric clinic to the clinic of the endodontic department of Isfahan University of Medical Sciences. SSRIs non-users were 45 women who did not take SSRIs referred for endodontic treatment to the same dental clinic.

You may qualify if:

• vital mandibular molar tooth
• diagnosis of symptomatic irreversible pulpitis

You may not qualify if:

• younger than 18 years old
• history of significant medical conditions
• allergies to local anesthetics or sulfites
• pregnancy
• active sites of pathosis in area of injection
• inability to give informed consent

Sponsors & Collaborators

• Isfahan University of Medical Sciences: lead

Study Sites (1)

School of Dentistry, Isfahan University of Medical Sciences

Isfahan, 81747673461, Iran

Location

MeSH Terms

Interventions

Selective Serotonin Reuptake Inhibitors

Intervention Hierarchy (Ancestors)

Neurotransmitter Uptake Inhibitors; Membrane Transport Modulators; Molecular Mechanisms of Pharmacological Action; Pharmacologic Actions; Chemical Actions and Uses; Neurotransmitter Agents; Serotonin Agents; Physiological Effects of Drugs

Study Officials

• Abbasali khademi

  Isfahan University of Medical Sciences

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Endodontics, School of Dentistry, Isfahan University of Medical Sciences

Study Record Dates

• First Submitted: August 21, 2016
• First Posted: August 31, 2016
• Study Start: June 1, 2015
• Primary Completion: February 1, 2016
• Study Completion: March 1, 2016
• Last Updated: February 15, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share

Locations

IR (1)