Occupational Respiratory Allergies and Gene-environment Interactions
ARPEIGE
1 other identifier
observational
400
1 country
12
Brief Summary
The purpose is to compare clinical, functional, professional and socio-economical characteristics of patients with occupational asthma and work aggravated asthma. Secondary purposes are:
- to evaluate diagnostic value of new non-invasive techniques such as exhaled nitric oxide and cytology of induced expectoration;
- to estimate medical-social becoming of diagnosed work-related asthma after one year;
- to establish a biobank of blood samples of individuals with work related asthma for measurement of cytokines and search for genetic polymorphisms associated with asthma.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2016
Longer than P75 for all trials
12 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 23, 2016
CompletedFirst Posted
Study publicly available on registry
August 26, 2016
CompletedStudy Start
First participant enrolled
September 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2020
CompletedAugust 26, 2016
August 1, 2016
4 years
August 23, 2016
August 23, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Classification of suspected work-related asthma in occupational asthma, work aggravated asthma, non-work-related asthma
Interpretation of diagnostic algorithm of study
Inclusion
Secondary Outcomes (6)
Nitric oxide level
Inclusion
Cytology of induced expectoration
Inclusion
Nonspecific bronchial hyperreactivity evaluated with metacholine bronchial challenge test and/or isocapnic hyperventilation test
Inclusion
Control of asthma symptoms evaluated with Asthma Control test and peak exploratory flow
Inclusion
Severity of symptoms
Inclusion
- +1 more secondary outcomes
Study Arms (3)
Occupational Asthma
Work Aggravated Asthma
Non-Work-Related Asthma
Interventions
Biobank. Analysis of cytokines and DNA polymorphisms
Eligibility Criteria
Men or women, professionally active, consulting in one of hospitals participating to the study for suspicion of work-related asthma .
You may qualify if:
- \- Patient consulting for suspected work-related asthma in one of hospitals participating to the study
You may not qualify if:
- Patient refusing to participate
- Pregnant or breastfeeding women
- Individual in life-threatening emergency
- Hospitalized patient
- Patient in a health or social institution
- Person deprived of liberty
- Person with total occupational disability
- Retired person
- Person diagnosed as non-asthmatic
- Asthmatic person already enrolled in a clinical trial of bio-therapy to treat asthma
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (12)
Centre de consultation de pathologies professionnelles, Hôpital Pellegrin - CHU de Bordeaux
Bordeaux, France
Centre de consultation de pathologies professionnelles, Hôpital côte de Nacre - CHU de Caen
Caen, France
Centre de consultation de pathologies professionnelles, Centre Hospitalier Intercommunal de Créteil
Créteil, France
Centre de consultation de pathologies professionnelles, Hôpital Michallon - CHU de Grenoble
Grenoble, France
Centre de consultation de pathologies professionnelles, immeuble Tourville - CHU de Nantes
Nantes, France
Centre de consultation de pathologies professionnelles, AP-HP groupe hospitalier Cochin
Paris, France
Centre de consultation de pathologies professionnelles, Hôpital Fernand-Widal
Paris, France
Centre de consultation de pathologies professionnelles, Centre Hospitalier Lyon-Sud
Pierre-Bénite, France
Centre de consultation de pathologies professionnelles, Hôpital Civil - CHU de Strasbourg
Strasbourg, France
Centre de consultation de pathologies professionnelles, Hôpital Lyautey - CHU de Strasbourg
Strasbourg, France
Centre de consultation de pathologies professionnelles, Hôpital Purpan - CHU de Toulouse
Toulouse, France
Centre de consultation de pathologies professionnelles, CHRU Nancy
Vandœuvre-lès-Nancy, France
Biospecimen
Blood sample for collection of human biological material for genotyping analysis
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christophe Paris
Centre de Consultation de Pathologies Professionnelles, CHRU Nancy
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 23, 2016
First Posted
August 26, 2016
Study Start
September 1, 2016
Primary Completion
September 1, 2020
Study Completion
September 1, 2020
Last Updated
August 26, 2016
Record last verified: 2016-08
Data Sharing
- IPD Sharing
- Will not share