NCT02872571|Active Not RecruitingPhase 1/2
Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy
AUTOGRAFTIM
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AUTOGRAFTIM
Sponsor study identifier
Secondary identifiers
OTHER · ID-RCB number, ANSM
interventional
35
1 country
4
Study Start
March 2013
Actual (reported)Primary Completion
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The liver may not be an optimal site for islet transplantation due to obstacles by an instant blood-mediated inflammatory response, and low revascularization of transplanted islets. Therefore, intramuscular islet transplantation offers an attractive alternative, based on its simplicity, enabling easier access for noninvasive graft imaging and cell explantation.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2013
Actual (reported)August 16, 2016
Actual (reported)August 19, 2016
Actual (reported)April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
the percentage of patients with a functioning graft in the arm 3 months after autograft.
Graft function will be estimated by the difference in insulin response between the two arms after the test stimulus by arginine (Acute Insulin Response or AIRarg) .The graft will be considered functional (success) when the insulin response in the grafted arm will be at least 30% higher compared to the other arm, 3 months after transplantation.
3 months
The percentage of patients with a functioning graft in the arm
6 months, 12 months
Continuous Glucose Monitoring System
at baseline ( before autograft) at 3,6,12 months
Oral Glucose Tolerance Test
at baseline ( before autograft) at 3,6,12 months
hemoglobin A1c (HbA1c) blood test
at baseline ( before autograft) at 3,6,12 months
Intramuscular Islet Autograft After Extensive Pancreatectomy
Intramuscular Islet Autograft After Extensive Pancreatectomy
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Chu Amiens Picardie
Amiens, France
CHRU, Hôpital Claude Huriez
Lille, France
Institut Paoli Calmettes
Marseille, France
CHU Rouen
Rouen, France
Pattou F, Kerr-Conte J, Wild D. GLP-1-receptor scanning for imaging of human beta cells transplanted in muscle. N Engl J Med. 2010 Sep 23;363(13):1289-90. doi: 10.1056/NEJMc1004547. No abstract available.
François Pattou, MD, PhD
University Hospital, Lille
First Submitted
August 16, 2016
First Posted
August 19, 2016
Study Start
March 2013
Actual (reported)Primary Completion
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Contact the study team to confirm eligibility.
Study Completion
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
April 22, 2026
Record last verified: 2026-04
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Source: ClinicalTrials.gov.
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