Volume of Perirenal Fat and Chronic Kidney Disease

NCT02870621 | Unknown

• 1 other identifier: 12-PP-06
• Study Type: observational
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The perirenal fat may alter renal function by secreting fibrotic inflammatory agents when accumulates during obesity. Nephrectomy for renal tumor is a model that would provide tissue samples to test this hypothesis. Renal tumor could itself be responsible for inflammation and fibrosis in its environment. This study aims to measure the influence of the tumor on his kidney Environment and fat and define molecular markers not influenced by renal tumor. The main objective is to compare the inflammation of the perirenal fat taken in two locations in the same patient, in contact and 4 cm from the outer edge of the tumor, each patient as his own control. The secondary objective is to compare the degree of interstitial fibrosis of the renal cortex in the same sampling methods.

Conditions

Nephrectomy

Outcome Measures

Primary Outcomes (1)

• Numbers of renal interstitial fibrosis

  1 day

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Recruitment is in hospital, all patients being hospitalized in case of nephrectomy for kidney cancer. The treatment will be done like habitually and fat will be sample.

You may qualify if:

• Age 18 years or more
• Indication nephrectomy for kidney tumor
• Stadium T1a, T1b or T2 and M0 according to the TNM (Tumor Nodes Metastasis) classification of tumors

You may not qualify if:

• Nephrectomy indication for chronic pyelonephritis
• Asian topic because of the difference threshold values used to characterize the metabolic syndrome in this population
• Diabetes type I or II due to a high score of renal interstitial fibrosis
• Infection with HIV (Human immunodeficiency virus)
• Partial nephrectomy (a part of the kidney on the side of the tumor is left in place)

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

CHU de Nice

Nice, France

RECRUITING

Central Study Contacts

Guillaume FAVRE, Dr

CONTACT

4 92 03 88 24; favre.g@chu-nice.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 29, 2016
• First Posted: August 17, 2016
• Study Start: July 1, 2012
• Primary Completion: September 1, 2016
• Last Updated: August 17, 2016

Record last verified: 2016-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)