Influence of Light on Sleep, Awakening, Electroencephalogram (EEG) and Cognitive Performances

NCT02858765 | Completed

• 1 other identifier: 6187
• Study Type: interventional
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this project is to study the influence of light on sleep, wakefulness, EEG activity and cognitive performances. The study aim also to evaluate techniques for registration and analysis of the EEG over periods of time.

Conditions

Human Sleep and Chronobiology

Outcome Measures

Primary Outcomes (13)

• Analysis of EEG activity

  sleep fragmentation

  up to 56 hours

• Cognitive performances assessed using Psychomotor vigilance task (PVT)

  Psychomotor vigilance task (PVT)

  up to 56 hours

• Cognitive performances assessed using Sustained Attention to Response Task (SART)

  Sustained Attention to Response Task (SART)

  up to 56 hours

• Cognitive performances assessed using Digit Symbol Substitution Test (DSST)

  Digit Symbol Substitution Test (DSST)

  up to 56 hours

• Cognitive performances assessed using N-back tasks

  N-back tasks

  up to 56 hours

• Cognitive performances assessed using Paced Visual Serial Addition Task (PVSAT)

  Paced Visual Serial Addition Task (PVSAT)

  up to 56 hours

• Cognitive performances assessed using Visual analogue scales (VAS) for motivation

  Visual analogue scales (VAS) for motivation

  up to 56 hours

• Cognitive performances assessed using Positive and Negative Affect Scale (PANAS)

  Positive and Negative Affect Scale (PANAS)

  up to 56 hours

• Cognitive performances assessed using Karolinska Sleepiness Scale (KSS)

  Karolinska Sleepiness Scale (KSS)

  up to 56 hours

• Cognitive performances assessed using Visual Comfort Scale (VCS)

  Visual Comfort Scale (VCS)

  up to 56 hours

• Cognitive performances assessed using Racing and Crowded Thoughts Questionnaire (RCTQ)

  Racing and Crowded Thoughts Questionnaire (RCTQ)

  up to 56 hours

• Cognitive performances assessed using Mental Effort Rating Scale (RSME)

  Mental Effort Rating Scale (RSME)

  up to 56 hours

• Cognitive performances assessed using Karolinska Drowsiness Test (KDT)

  Karolinska Drowsiness Test (KDT)

  up to 56 hours

Study Arms (4)

white polychromatic light A

EXPERIMENTAL

Other: Application of white polychromatic light for 2h30 at different times of day

white polychromatic light B

EXPERIMENTAL

Other: Application of white polychromatic light for 2h30 at different times of day

white polychromatic light C

EXPERIMENTAL

Other: Application of white polychromatic light for 2h30 at different times of day

white polychromatic light D

EXPERIMENTAL

Other: Application of white polychromatic light for 2h30 at different times of day

Interventions

Application of white polychromatic light for 2h30 at different times of day OTHER

white polychromatic light A; white polychromatic light B; white polychromatic light C; white polychromatic light D

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female
• Aged 18 to 40 years
• With a hint of Bodymass index (BMI) between 17 and 30 kg.m - 2
• Healthy subject determined by a clinical examination, a psychological interview, a blood test, a urine analysis and an ophthalmologic examination
• Topic Subject with a score \<6 questionnaire PSQI ("Sleep Questionnaire Pittsburgh")
• Subject agreeing to maintain a regular sleep/wake rhythm during the study
• Subject agreeing to refrain from caffeine, nicotine, alcohol, psychotropic drugs, cannabis or other drugs during the study
• Signed informed consent
• Subject affiliated to a social protection scheme

You may not qualify if:

• somatic diseases: cardiovascular, respiratory, gastrointestinal, hematopoietic, Visual
• immune system diseases
• kidneys and urinary tract diseases
• endocrine and metabolic diseases
• neurological diseases
• infectious diseases
• thrombocytopenia or other malfunction of blood platelets
• Subject with risk of thrombosis, including subject with a history of phlebitis, smoker under oral contraceptive...
• Subject with an addiction to caffeine, nicotine, alcohol, psychotropic drugs, cannabis, or any other drug
• Subject treatment contraindicated or inadvisable in combination with heparin
• Allergy to neoprene or lycra
• Dysfunction of the temporomandibular joint (TMJD)
• Contraindications to the use of the medical device
• Impossibility to give enlightened information (subject in an emergency situation, understanding difficulties,...)
• Subject under safeguard of justice

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Hôpitaux Universitaires de Strasbourg

Strasbourg, 67091, France

Location

Related Publications (2)

• Glacet R, Reynaud E, Robin-Choteau L, Reix N, Hugueny L, Ruppert E, Geoffroy PA, Kilic-Huck U, Comtet H, Bourgin P. A comparison of four methods to estimate dim light melatonin onset: a repeatability and agreement study. Chronobiol Int. 2023 Feb;40(2):123-131. doi: 10.1080/07420528.2022.2150554. Epub 2022 Dec 15.

  PMID: 36519316 RESULT

• Walter A, Martz E, Weiner L, Comtet H, Glacet R, Kilic-Huck U, Bourgin P, Schroder CM, Weibel S. Sleep, rest-activity rhythm, cognitive and emotional symptoms in adult ADHD: unraveling the links with an actimetry-based approach. BMC Psychiatry. 2026 Mar 9. doi: 10.1186/s12888-026-07947-9. Online ahead of print.

  PMID: 41803808 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 30, 2016
• First Posted: August 8, 2016
• Study Start: June 1, 2016
• Primary Completion: June 1, 2019
• Study Completion: June 1, 2019
• Last Updated: December 19, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)